Long non‑coding RNAs in lung cancer: Regulation patterns, biologic function and diagnosis implications (Review)

Area of Science:

• Oncology
• Molecular Biology
• Genomics

Background:

• Lung cancer is a leading cause of cancer mortality globally.
• Long non-coding RNAs (lncRNAs) are increasingly recognized as crucial regulators in various cancers.
• Dysregulation of lncRNAs plays a significant role in lung cancer initiation, progression, and response to therapy.

Purpose of the Study:

• To summarize the causal effects of dysregulated lncRNAs in lung cancer.
• To discuss the mechanisms of lncRNA-mediated tumorigenesis, metastasis, and drug resistance.
• To explore the potential of lncRNAs as biomarkers for lung cancer.

Main Methods:

• Literature review of studies on lncRNAs in lung cancer.
• Analysis of lncRNA functions including interactions with DNA, RNA, and proteins.
• Evaluation of lncRNAs as tumor suppressors or oncogenes.

Main Results:

• lncRNAs are commonly dysregulated in lung cancer.
• lncRNAs influence gene expression and cell signaling pathways.
• lncRNAs have roles in tumor initiation, progression, metastasis, and drug resistance.

Conclusions:

• Dysregulated lncRNAs are key players in lung cancer pathogenesis.
• lncRNAs hold promise as diagnostic and prognostic biomarkers for lung cancer.
• Targeting lncRNAs may offer novel therapeutic strategies for lung cancer.