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According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
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A nursing care plan can present in two forms: informal and formal. Informal is a care plan for the individual use of the nurse and goals they wish to accomplish during their shift. Informal care plans are not included in the patient chart. A formal nursing care plan is a written or computerized guide that organizes patient care. It is further subdivided into two: standardized and individualized care plans. Standardized care plans are pre-populated care plans for specific patient populations,...
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Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
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Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
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Three IMRT advanced planning tools: A multi-institutional side-by-side comparison.

Lan Lu1, Yang Sheng2, Jeremy Donaghue3

  • 1Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.

Journal of Applied Clinical Medical Physics
|August 1, 2019
PubMed
Summary
This summary is machine-generated.

Advanced radiation therapy planning tools improve intensity-modulated radiation therapy (IMRT) quality, especially for head and neck (HN) cancers. These tools offer consistency and reduced organ-at-risk doses compared to manual planning.

Keywords:
auto-planningknowledge-based planningmultiple criteria optimization

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Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Cancer Treatment

Background:

  • Intensity-modulated radiation therapy (IMRT) is a cornerstone of modern cancer treatment.
  • Manual treatment planning requires significant expertise and can lead to plan variability.
  • Advanced planning tools aim to enhance IMRT plan quality and consistency.

Purpose of the Study:

  • To evaluate three advanced IMRT treatment planning tools: auto-planning, knowledge-based planning, and multiple criteria optimization.
  • To compare the quality and consistency of plans generated by these tools against clinically approved manual plans.
  • To assess performance across various cancer sites: head and neck (HN), brain, prostate, and spine.

Main Methods:

  • Retrospective analysis of 20 clinical cases (5 per site) from Cleveland Clinic.
  • Three institutions, each expert in one advanced tool, planned cases using shared objectives and constraints.
  • Comparison of isodose distributions, dose-volume histograms, and dosimetric endpoints between manual and advanced plans.

Main Results:

  • Advanced tools significantly improved plan quality for HN cancer cases, reducing doses to the spinal cord, brainstem, and parotid glands.
  • For brain, prostate, and spine cases, advanced plans showed comparable dosimetric endpoints to manual plans.
  • Overall, advanced tools demonstrated potential for improved plan consistency with minimal planner intervention.

Conclusions:

  • Advanced treatment planning tools are clinically valuable, matching or exceeding manual plan quality.
  • These tools enhance consistency in IMRT planning.
  • They are particularly beneficial for complex cases like HN cancer, optimizing organ-at-risk sparing.