Related Experiment Video
Updated: Jan 21, 2026
07:13
A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
Published on: April 30, 2020
6.9K
Subclinical biventricular systolic dysfunction in patients with systemic sclerosis
Şükrü Taylan Şahin1, Neslihan Yılmaz2, Betül Cengiz1
1Department of Cardiology, İstanbul Bilim University School of Medicine, İstanbul, Turkey.
European Journal of Rheumatology
|August 1, 2019
Summary
Systemic sclerosis (SSc) patients show impaired biventricular systolic function, detectable by strain imaging. Speckle tracking and 3D echocardiography reveal subclinical myocardial dysfunction in SSc, impacting prognosis.
Area of Science:
- Cardiology
- Rheumatology
- Medical Imaging
Background:
- Systemic sclerosis (SSc) is linked to poor prognosis, often due to silent myocardial involvement.
- Early detection of cardiac dysfunction is crucial for managing SSc patients.
Purpose of the Study:
- To evaluate subclinical left ventricular (LV) and right ventricular (RV) systolic dysfunction in SSc patients without prior cardiovascular disease.
- To utilize speckle tracking echocardiography (STE) and real-time 3D echocardiography (RT3DE) for assessing biventricular deformation.
Main Methods:
- Studied 47 SSc patients and 20 healthy controls (HC).
- Performed conventional echocardiography, STE-based strain imaging, and RT3DE to assess biventricular systolic function.
- Correlated cardiac function with clinical and serological findings.
Main Results:
- LV measurements were similar between SSc and HC groups.
- Significantly impaired LV and RV longitudinal peak systolic strain/strain rates observed in SSc patients, indicating subclinical dysfunction (p≤0.001).
- Pulmonary artery pressure negatively correlated with LV and RV strain; a trend for decreasing LV strain over 1 year was noted.
Conclusions:
- Systemic sclerosis is associated with myocardial systolic dysfunction.
- STE and RT3DE are promising non-invasive tools for comprehensive assessment of biventricular systolic function in SSc.
- These imaging modalities can detect subtle cardiac deterioration in SSc patients.
Related Concept Videos
01:18Second Order systems II
390
In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
390
01:21First Order Systems
403
First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
403
01:20Second Order systems I
575
A servo system exemplifies a second-order system, featuring a proportional controller and load elements that ensure the output position aligns with the input position. The relationship between these components is described by a second-order differential equation. Applying the Laplace transform under zero initial conditions yields the transfer function, showing how inputs are converted to outputs in the system.
By reinterpreting the system, one can derive the closed-loop transfer function, which...
By reinterpreting the system, one can derive the closed-loop transfer function, which...
575
01:26Classification of Systems-I
554
Linearity is a system property characterized by a direct input-output relationship, combining homogeneity and additivity.
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
554
01:31Classification of Systems-II
460
Continuous-time systems have continuous input and output signals, with time measured continuously. These systems are generally defined by differential or algebraic equations. For instance, in an RC circuit, the relationship between input and output voltage is expressed through a differential equation derived from Ohm's law and the capacitor relation,
460
01:22Mechanical Systems
597
Mechanical systems are analogous to to electrical networks where springs and masses play similar roles to inductors and capacitors, respectively. A viscous damper in mechanical systems functions similarly to a resistor in electrical networks, dissipating energy. The forces acting on a mass in such systems include an applied force in the direction of motion, counteracted by forces from the spring, a viscous damper, and the mass's acceleration. This interplay of forces is mathematically...
597