Related Experiment Video
Updated: Jul 13, 2026
10:26
The Infiltration-centrifugation Technique for Extraction of Apoplastic Fluid from Plant Leaves Using Phaseolus vulgaris as an Example
Published on: December 19, 2014
38.5K
Pemphigus vulgaris
Adriana Maria Porro1, Camila Arai Seque1, Maria Carolina Corsi Ferreira1
1Department of Dermatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Anais Brasileiros De Dermatologia
|August 1, 2019
Summary
Pemphigus vulgaris is a severe autoimmune skin disease caused by antibodies against desmogleins. Treatment involves corticosteroids and immunosuppressants, with rituximab showing promise for severe cases.
Area of Science:
- Dermatology
- Autoimmunology
- Immunodermatology
Background:
- Pemphigus vulgaris is a chronic autoimmune bullous dermatosis.
- It is characterized by autoantibodies against desmogleins 1 and 3.
- This is the most frequent and severe form of pemphigus, affecting individuals typically between 40 and 60 years of age.
Purpose of the Study:
- To provide a comprehensive overview of Pemphigus Vulgaris.
- To discuss its clinical presentation, diagnosis, and management.
- To highlight the chronic nature and mortality associated with the disease.
Main Methods:
- Clinical suspicion is confirmed through cytological examination.
- Histopathological examination aids in diagnosis.
- Direct and indirect immunofluorescence tests are crucial for confirmation.
Main Results:
- The disease typically begins with oral mucosal blisters and erosions.
- Skin lesions manifest as flaccid blisters, which can be widespread.
- A variant, pemphigus vegetans, presents with vegetating lesions in skin folds.
Conclusions:
- Treatment includes systemic corticosteroids and immunosuppressive drugs like azathioprine and mycophenolate mofetil.
- Intravenous pulse corticosteroid therapy and rituximab are options for severe cases.
- Pemphigus vulgaris is a chronic condition with a 10% mortality rate, primarily due to septicemia, necessitating long-term multidisciplinary care.
Related Concept Videos
01:05Desmosomes
The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:30Peptic Ulcer Disease I: Introduction
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
01:27Peptic Ulcer
Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the mucus...
01:25Peptic Ulcer Disease I: Introduction
Peptic ulcer disease (PUD) involves breaks in the gastrointestinal tract's mucosal lining, primarily in the stomach and duodenum, with less frequent occurrences in the lower esophagus or near the pylorus.Ulcers can be acute or chronic. Acute ulcers are short-lived with minimal inflammation and heal quickly after the irritant is removed. Chronic ulcers persist, may recur, and often cause scarring due to ongoing tissue damage. Superficial erosions affect only the mucosal layer and are called...