Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IgM-mesangial nephropathy in callithricids.

M Brack1

  • 1German Primate Center, Göttingen, Federal Republic of Germany.

Veterinary Pathology
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pre-infection of pigs with Mycoplasma hyopneumoniae induces oxidative stress that influences outcomes of a subsequent infection with a swine influenza virus of H1N1 subtype.

Veterinary microbiology·2012
Same author

[Oxidative stress and fertility: false evidence and bad recipes].

Gynecologie, obstetrique & fertilite·2012
Same author

Semiclassical theory for spatial density oscillations in fermionic systems.

Physical review. E, Statistical, nonlinear, and soft matter physics·2010
Same author

A machine-learning approach to the prediction of oxidative stress in chronic inflammatory disease.

Redox report : communications in free radical research·2009
Same author

Periodic orbit theory for the Hénon-Heiles system in the continuum region.

Physical review. E, Statistical, nonlinear, and soft matter physics·2005
Same author

Semiclassical trace formulas for pitchfork bifurcation sequences.

Physical review. E, Statistical, nonlinear, and soft matter physics·2004
Same journal

Performance evaluation of deep learning models for image analysis: Considerations for visual assessment and statistical metrics.

Veterinary pathology·2026
Same journal

Benign epithelial inclusions in renal hilar lymph nodes of a cynomolgus monkey (<i>Macaca fascicularis</i>).

Veterinary pathology·2026
Same journal

An outbreak of H5N1 clade 2.3.4.4b highly pathogenic avian influenza in California condors (<i>Gymnogyps californianus)</i>.

Veterinary pathology·2026
Same journal

Histomorphologic evidence supports a hyperplastic pathogenesis of fibromatous epulis of periodontal ligament origin/peripheral odontogenic fibroma and proposal of fibromatous hyperplasia of the gingival ligament as unifying nomenclature.

Veterinary pathology·2026
Same journal

Image challenge in <i>veterinary pathology</i>.

Veterinary pathology·2026
Same journal

Image challenge in veterinary pathology, answers: Bovine diseases.

Veterinary pathology·2026
See all related articles

A common kidney disease, IgM-mediated mesangioproliferative nephropathy, affects over 90% of older tamarins and marmosets. This progressive, often silent condition is linked to 20% of animal deaths, indicating a significant immunological basis.

Area of Science:

  • Veterinary Pathology
  • Immunology
  • Primate Medicine

Background:

  • Spontaneous kidney disease is a concern in non-human primates.
  • Mesangioproliferative nephropathy has been observed in various primate species.

Purpose of the Study:

  • To characterize the incidence, progression, and underlying mechanisms of spontaneous mesangioproliferative nephropathy in tamarins and marmosets.
  • To investigate the role of immunoglobulin M (IgM) and complement component 3 (C3) in the pathogenesis of this renal lesion.

Main Methods:

  • Histopathological examination of kidney tissues from tamarins and marmosets.
  • Immunohistochemical staining for IgM and C3 deposition.
  • Correlation of renal lesions with animal age and cause of death.

Related Experiment Videos

Main Results:

  • 91% of tamarins and marmosets over 6 months old exhibited IgM-mediated mesangioproliferative nephropathy.
  • The disease is characterized by mesangial hyperplasia and interstitial inflammation.
  • IgM deposition in mesangial cells/matrix and C3 in the interstitium suggest an immune-mediated process.
  • The condition is progressive, often asymptomatic, and implicated in 20% of animal mortality.

Conclusions:

  • Spontaneous IgM-mediated mesangioproliferative nephropathy is highly prevalent in aged tamarins and marmosets.
  • The pathogenesis involves immune mechanisms, likely antibody-mediated.
  • This nephropathy represents a significant health issue in these primate populations, contributing to mortality.