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Establishment of Human Epithelial Enteroids and Colonoids from Whole Tissue and Biopsy
Published on: March 6, 2015
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Limited Tissue Biopsies and Hematolymphoid Neoplasms
Kimberly F Ingersoll1, Yue Zhao1,2, Grant P Harrison3
1Department of Pathology, Duke University Hospital, Durham, NC.
American Journal of Clinical Pathology
|August 1, 2019
Summary
Fine-needle aspiration/needle core biopsy (FNA/CNB) is effective for diagnosing hematolymphoid lesions, especially in recurrent lymphoma cases. This minimally invasive method offers high diagnostic accuracy in various settings.
Area of Science:
- Hematopathology
- Oncology
- Diagnostic Cytology
Background:
- The utility of fine-needle aspiration/needle core biopsy (FNA/CNB) for hematolymphoid processes remains a subject of discussion.
- Evaluating these lesions often requires careful consideration of clinicopathologic context.
Purpose of the Study:
- To investigate the applicability and diagnostic efficacy of FNA/CNB in diverse hematolymphoid conditions.
- To determine the diagnostic yield of FNA/CNB compared to excisional biopsies.
Main Methods:
- Retrospective analysis of 152 FNA/CNB cases.
- Stratification of results based on clinical history (e.g., lymphoma relapse, immunodeficiency) and disease type.
Main Results:
- FNA/CNB provided diagnoses without excisional biopsy in 81.6% of cases.
- Diagnostic rates were significantly higher for lymphoma relapse (95.4%) and in immunodeficient patients (100%).
- Diffuse large B-cell lymphoma showed a higher success rate than small B-cell lymphoma, though not statistically significant.
Conclusions:
- FNA/CNB is a practical and effective tool for evaluating most hematolymphoid lesions.
- The procedure demonstrates high efficacy in recurrent disease and specific primary neoplasms.
- Careful interpretation is needed for complex or unusual cases.
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