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Catestatin in Acutely Decompensated Heart Failure Patients: Insights from the CATSTAT-HF Study

Josip A Borovac1,2,3, Duska Glavas3,4, Zora Susilovic Grabovac3

  • 1Department of Pathophysiology, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia.

Journal of Clinical Medicine
|August 2, 2019
PubMed

Insights

Catestatin (CST) levels are higher in acutely decompensated heart failure (ADHF) patients with a history of myocardial infarction (MI). Higher CST levels in ADHF patients are associated with a better cardiometabolic profile but indicate increased symptomatic burden.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • The role of catestatin (CST) in acutely decompensated heart failure (ADHF) and myocardial infarction (MI) is not well understood.
  • CST is implicated in regulating neurohumoral activity, suggesting a potential role in cardiovascular pathophysiology.

Purpose of the Study:

  • To determine serum CST levels in ADHF patients, specifically in relation to MI history and left ventricular ejection fraction (LVEF).
  • To investigate the association of CST levels with clinical, echocardiographic, and laboratory parameters in ADHF patients.

Main Methods:

  • Ninety consecutively enrolled ADHF patients were assessed for serum CST levels.
  • Patients were stratified based on MI history and LVEF.
  • Multivariable linear regression analysis was used to identify independent correlates of CST levels.

Main Results:

  • CST levels were significantly higher in ADHF patients with a history of MI compared to those without (8.94 ± 6.39 vs. 4.90 ± 2.74 ng/mL, p = 0.001).
  • No significant difference in CST levels was observed across different LVEF categories (reduced, midrange, preserved).
  • CST independently correlated with NYHA class, waist-to-hip ratio, HbA1c, LDL, non-HDL cholesterol, hs-cTnI, and heart rate.

Conclusions:

  • Serum CST levels are elevated in ADHF patients with MI history.
  • Higher CST levels in ADHF are associated with a favorable cardiometabolic profile but also reflect a greater symptomatic burden.
  • CST may serve as a potential biomarker in ADHF, reflecting both cardiovascular history and metabolic status.

Keywords:
NT-proBNPNYHA functional classacute myocardial infarctionbiomarkerscatestatincoronary artery diseaseheart failureheart failure decompensationleft ventricular ejection fractiontroponin

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