Current Position of the Molecular Therapeutic Targets for Ovarian Clear Cell Carcinoma: A Literature Review

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Ovarian clear cell carcinoma (OCCC) exhibits poor response to traditional chemotherapy, particularly in advanced stages.
• Developing novel therapeutic strategies and precision medicine is crucial for improving OCCC patient outcomes.

Purpose of the Study:

• To review recent advancements in understanding OCCC molecular characteristics.
• To identify future directions for precision medicine and combinatorial therapies in OCCC treatment.

Main Methods:

• Literature review of recent studies on OCCC molecular targets.
• Categorization of identified molecular targets into four key areas.
• Analysis of in vitro and in vivo data for OCCC cell suppression.

Main Results:

• Identified four main categories of molecular targets for OCCC: receptor tyrosine kinase pathways, anti-oxidative stress molecules, ARID1A-related chromatin remodeling errors, and immune checkpoint inhibitors (anti-PD-L1/PD-1).
• Numerous inhibitors targeting these pathways have shown efficacy in preclinical studies.
• Current single-agent therapies have not yet demonstrated sufficient clinical effectiveness.

Conclusions:

• Despite promising preclinical results, single targeted therapies are insufficient for OCCC.
• Future research should focus on combinatorial therapies and further exploration of molecular targets for OCCC.
• Advancing precision medicine approaches is key to overcoming treatment resistance in OCCC.