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Sorafenib and Palbociclib Combination Regresses a Cisplatinum-resistant Osteosarcoma in a PDOX Mouse Model

Takashi Higuchi1,2,3, Norihiko Sugisawa1,2, Kentaro Miyake1,2

  • 1AntiCancer, Inc., San Diego, CA, U.S.A.

Anticancer Research
|August 2, 2019
PubMed
Abstract

Insights

The combination of sorafenib (SFN) and palbociclib (PAL) effectively treated osteosarcoma in a preclinical model. This novel strategy significantly reduced tumor growth and increased necrosis in cisplatinum-resistant osteosarcoma.

Area of Science:

  • Oncology
  • Pharmacology
  • Preclinical Research

Background:

  • Recurrent osteosarcoma presents a significant therapeutic challenge, necessitating novel treatment strategies.
  • Patient-derived orthotopic xenograft (PDOX) models are crucial for developing effective osteosarcoma therapies.
  • The efficacy of sorafenib (SFN) and palbociclib (PAL) combination in osteosarcoma remains unexplored.

Purpose of the Study:

  • To evaluate the therapeutic efficacy of the SFN and PAL combination.
  • To assess the SFN and PAL combination in a cisplatinum (CDDP)-resistant osteosarcoma PDOX model.

Main Methods:

  • Osteosarcoma PDOX models were established.
  • Models were randomized into five groups: control, CDDP, SFN, PAL, and SFN + PAL combination.
  • Tumor growth and necrosis were assessed.

Main Results:

  • The SFN + PAL combination significantly inhibited osteosarcoma tumor growth in PDOX models.
  • Enhanced tumor necrosis and degenerative changes were observed with the SFN + PAL combination.
  • The combination demonstrated superior efficacy compared to individual agents or CDDP.

Conclusions:

  • The SFN + PAL combination represents a promising therapeutic strategy for osteosarcoma.
  • This combination therapy holds potential for clinical application in treating osteosarcoma, particularly resistant forms.
Keywords:
OsteosarcomaPDOXcombination therapypalbociclibsorafenib

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