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Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
Published on: July 19, 2019
Low IRBIT Levels Are Associated With Chemo-resistance in Gastric Cancer Patients
Nobuhiro Nakazawa1, Kyoichi Ogata1, Takehiko Yokobori2
1Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Japan kogata@gunma-u.ac.jp bori45@gunma-u.ac.jp nakazawa75@yahoo.co.jp.
Background/Aim:
We investigated whether the expression of inositol 1, 4, 5-trisphosphate receptor-binding protein released with inositol 1, 4, 5-trisphosphate (IRBIT) in clinical gastric cancer (GC) patients could predict the therapeutic response to postoperative adjuvant chemotherapy.
Materials And Methods:
Immunohistochemistry was used to investigate IRBIT expression in 115 GC patients. To clarify whether IRBIT had a relationship with the therapeutic effects of chemotherapy, we compared two groups - 62 patients treated with postoperative adjuvant chemotherapy and 53 patients treated with postoperative adjuvant chemotherapy.
Results:
Regarding the postoperative adjuvant chemotherapy-free group, we did not find any statistically significant correlation between clinicopathological features and recurrence regardless of the expression of IRBIT. In contrast, in the group receiving postoperative adjuvant chemotherapy, a significant association was found between IRBIT expression and both overall and disease-free survival.
Conclusion:
IRBIT may be used as a useful predictive marker for chemotherapy.
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