Related Experiment Video
Updated: Jan 21, 2026
Generation of Murine Primary Colon Epithelial Monolayers from Intestinal Crypts
Published on: February 6, 2021
Dissecting the Microscopic Anatomy of Colon Crypts in Non-dysplastic Sessile Serrated Polyps
Carlos A Rubio1, Peter T Schmidt2
1Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden Carlos.Rubio@ki.se.
Background/Aim:
Sessile serrated polyps (SSP) are characterized by crypts with corrupted shapes (CCS).
Materials And Methods:
The number of CCS and the lateral size of 60 non-dysplastic SSP (NDSSP) were investigated.
Results:
Out of 60 NDSSP, 34 were small (≤9 mm) and 26, large (≥10 mm). In total, 1,101 CCS were recorded: 547 CCS were connected to the lumen (CCSL) and 554 CCS were not (CCSNL). The lateral size of NDSSP, the total number of CCS and the number of CCSNL were significantly higher in large NDSSP than in small NDSSP. Conversely, the number of CCS connected to the lumen/mm (CCSL/mm) and of crypts with normal shapes connected to the lumen/mm (CCSNL/mm), were significantly lower in large NDSSP than in small NDSSP.
Conclusion:
The lateral expansion of large NDSSP ensues via increased numbers of CCS at the expense of a decreased number of both CCSL/mm and CCSNL/mm.
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