Related Experiment Video
Updated: Jan 21, 2026
05:06
A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
12.8K
Hepatocellular carcinoma - time to take the ticket
Anju Mullath1, Murali Krishna2
1Department of Gastroenterology, Lakeshore Hospital and Research Centre, Kochi 682040, Kerala, India.
World Journal of Gastrointestinal Surgery
|August 2, 2019
Summary
Hepatocellular carcinoma (HCC) patients outside Milan criteria may still benefit from liver transplantation. This review explores alternative selection criteria and recurrence prediction using alpha-fetoprotein and PET scans for better HCC management.
Area of Science:
- Hepatology and Oncology
- Transplantation Medicine
Background:
- Hepatocellular carcinoma (HCC) is a major global cancer.
- Liver transplantation is a key treatment for early HCC.
- Milan criteria are standard for HCC transplant selection.
Purpose of the Study:
- To review HCC transplant selection criteria beyond Milan criteria.
- To evaluate alpha-fetoprotein (AFP) and PET scans for recurrence prediction.
Main Methods:
- Literature review of studies on HCC transplant selection.
- Analysis of data on alternative criteria and recurrence predictors.
Main Results:
- Emerging evidence supports transplantation for select HCC patients outside Milan criteria.
- AFP levels and PET scan findings show potential in predicting HCC recurrence.
Conclusions:
- Current Milan criteria may be too restrictive for HCC transplantation.
- Alternative criteria and recurrence prediction tools can optimize patient selection and post-transplant outcomes.
Related Concept Videos
01:22Generation Time
1.4K
Bacterial generation time, the period required for a bacterial population to double during its exponential growth phase, serves as a critical measure of microbial growth dynamics under optimal conditions. This parameter varies significantly across bacterial species and can be influenced by factors such as temperature, pH, and the availability of nutrients. For example, Escherichia coli can achieve a generation time of approximately 20 minutes, while Mycobacterium tuberculosis exhibits a much...
1.4K
01:19Mixing Time
462
The concept of mixing time is significant in producing a uniform concrete mix with the required strength. The mixing period starts once all components are in the mixer. Initially, the mixer is charged with 10% of the water, followed by the consistent addition of solids and then 80% of the water. The remaining water is added later, within the first quarter of the mixing period. The minimum mixing time varies according to the mixer's capacity; for example, mixers with up to 1 cubic yard...
462
01:22Mean free path and Mean free time
5.0K
Consider the gas molecules in a cylinder. They move in a random motion as they collide with each other and change speed and direction. The average of all the path lengths between collisions is known as the "mean free path."
5.0K
01:14Time Course of Drug Effect
2.6K
The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50...
2.6K
01:12Setting Time of Cement
617
The setting time of cement refers to the process of cement paste transitioning from a plastic state to a solid state. This process is crucial in construction as it dictates the timeframe for concrete placement, compaction, and finishing. The onset of this solidification is termed the initial set, indicating when the paste becomes unworkable. The final set is when the paste has solidified completely, and further handling or manipulation can no longer affect its shape. The cement strength is...
617
01:08Timing and Consequences on Behavior
366
In operant conditioning, the timing of reinforcement is crucial. For animals like rats and cats, immediate reinforcement (within a few seconds) is much more effective than delayed reinforcement. For example, a food reward for a rat needs to follow within 30 seconds of pressing a bar to be effective.
Humans, however, can respond to delayed reinforcers. We often make decisions between immediate small rewards and delayed larger rewards. This ability to delay gratification is a significant...
Humans, however, can respond to delayed reinforcers. We often make decisions between immediate small rewards and delayed larger rewards. This ability to delay gratification is a significant...
366