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[Transcutaneous trinitrine. Calling into question the efficacy and innocousness of its use in facilitating venous
Insights
Topical trinitrine pomade in infants led to high blood levels, halting the study. Further research is needed before considering this method for improving infant injection or sampling techniques.
Area of Science:
- Pharmacology
- Pediatric Medicine
Context:
- Transdermal drug delivery in infants presents unique challenges.
- Trinitrine (nitroglycerin) is a vasodilator with potential systemic effects.
Purpose:
- To evaluate the safety and efficacy of a topical trinitrine pomade in infants.
- To assess systemic absorption of trinitrine via transdermal application in a pediatric population.
Summary:
- Seven infants (6 days to 9 months) received a 1 mg trinitrine pomade via rubbing.
- The study was prematurely terminated due to significant systemic absorption of trinitrine into the bloodstream.
- No overt clinical side effects were observed, but systemic passage was a concern.
Impact:
- Highlights the risks of transdermal drug administration in neonates and infants.
- Suggests caution and further investigation are required before using trinitrine pomades in infants.
- Underscores the need for specialized techniques for pediatric intravenous injections or sampling.
Abstract:
Seven infants aged 6 days to 9 months were tested for the use by rubbing of a pomade containing 1 mg trinitrine. The study was interrupted because of high blood passage of trinitrine. The authors emphasize the difficulty of any comparison with the use of this drug in adults. They indicate that there was no clinically appreciable side-effect but they advise to delay, until further studies, the use of this technique, with the only objective of improving the technique of intravenous injections or sampling.