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Related Experiment Video

Updated: Jan 21, 2026

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

Programmable RNA manipulation in living cells.

Yu Pei¹, Mingxing Lu²

¹Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Cellular and Molecular Life Sciences : CMLS

|August 2, 2019

Summary

This summary is machine-generated.

New RNA-targeting tools like CRISPR-Cas systems and programmable RNA-binding proteins offer unprecedented control over gene expression. These technologies enable precise manipulation of RNA, advancing molecular biology research.

Keywords:

APEX2 CRISPR Cas13 Cas9 PPR PUF RNA-binding proteins bioID

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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Area of Science:

Molecular Biology
Genetics
Biotechnology

Background:

RNA molecules are central to genetic information flow, regulating processes like splicing, modification, and translation.
Current biological tools for programmable RNA manipulation are limited, hindering in-depth study.

Purpose of the Study:

To review recent advancements in RNA-targeting systems.
To highlight tools enabling programmable, transcript-specific gene expression control.

Main Methods:

Review of existing literature on RNA-targeting technologies.
Focus on CRISPR-based systems (Cas9, Cas13) and programmable RNA-binding proteins (PUF, PPR).

Main Results:

Identification and summary of emerging RNA-targeting systems.
Demonstration of transcript-specific manipulation capabilities.

Conclusions:

Advances in RNA-targeting technologies provide powerful new methods for molecular research.
These tools facilitate precise control over gene expression at the RNA level.