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Circulating Selenium and Cardiovascular or All-Cause Mortality in the General Population: a Meta-Analysis
Shouyan Xiang1, Zhe Dai1, Changfeng Man1
1Institute of Molecular Biology & Translational Medicine, the Affiliated People's Hospital, Jiangsu University, No. 8 Dianli Road,, ZhenJiang, 212002, China.
Biological Trace Element Research
|August 2, 2019
Summary
Low circulating selenium levels are linked to increased cardiovascular and all-cause mortality risk in the general population. However, low selenium did not significantly impact coronary death risk.
Area of Science:
- Nutritional Epidemiology
- Cardiovascular Health
- Public Health
Background:
- The relationship between circulating selenium levels and mortality is debated.
- Selenium is an essential trace element crucial for various physiological functions.
- Understanding selenium's role in mortality is vital for public health recommendations.
Purpose of the Study:
- To investigate the association between elevated circulating selenium levels and mortality.
- To analyze the link between selenium status and cardiovascular or all-cause mortality in the general population.
Main Methods:
- Systematic meta-analysis of observational studies and randomized controlled trial post hoc analyses.
- Searched PubMed and Embase databases up to January 20, 2019.
- Included 12 studies with 25,667 participants, comparing lowest vs. highest selenium levels and analyzing selenium as a continuous variable.
Main Results:
- Higher circulating selenium levels were associated with lower all-cause mortality (RR 1.36) and cardiovascular mortality (RR 1.35).
- Each standard deviation increase in selenium significantly reduced all-cause mortality risk by 20%.
- Low selenium levels were not significantly associated with increased coronary mortality (RR 1.43).
Conclusions:
- Low circulating selenium levels are associated with an increased risk of cardiovascular and all-cause mortality in the general population.
- Selenium status may be an important factor in cardiovascular health and overall longevity.
- Further research may be needed to clarify the specific impact on coronary mortality.
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