Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...

Overview of the Cardiovascular System

Overview of the Cardiovascular System

The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...

Regulation of the Cardiovascular System

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...

Exercise and Cardiovascular Response

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

Assessment of the Cardiovascular System II: Inspection

Assessment of the Cardiovascular System II: Inspection

Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
Head and Neck

Assessment of the Cardiovascular System IV: Auscultation

Assessment of the Cardiovascular System IV: Auscultation

Cardiac auscultation is a clinical skill used to assess heart function and detect abnormalities. It involves listening to heart sounds at specific anatomical locations through a stethoscope.
Normal Heart Sounds
S1 (First Heart Sound)-
S1 is made by the closure of the mitral and tricuspid valves (atrioventricular valves), marking the beginning of systole.
S2 (Second Heart Sound)-
S2 is made by the closure of the aortic and pulmonic valves (semilunar valves), marking the end of the systole.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Common human ALDH1B1 and ALDH2 variants increase neuroinflammatory response to a single ethanol dose in mice.

Science advances·2026

Same author

Mitochondrial vulnerability to aldehydic load and the role mitochondrial aldehyde dehydrogenases.

Pharmacological research·2026

Same author

Integrating genetic and lifestyle determinants in a risk prediction model for esophageal squamous cell carcinoma in Taiwan.

Scientific reports·2026

Same author

Targeting competitive Fe-S regulation to treat Friedreich's ataxia.

Trends in pharmacological sciences·2026

Same author

Increased susceptibility to 4-HNE-induced toxicity and impaired development in a model of ALDH4A1-deficient pediatric epilepsy carrying the S352L variant.

Communications biology·2026

Same author

cAMP and mitochondrial dysfunction in cancer cachexia.

Trends in molecular medicine·2026

Search research articles

Related Experiment Video

Updated: Jan 21, 2026

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

ALDH2 and Cardiovascular Disease.

Che-Hong Chen¹, Julio C B Ferreira², Daria Mochly-Rosen³

¹Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA, USA.

Advances in Experimental Medicine and Biology

|August 2, 2019

Summary

This summary is machine-generated.

Aldehyde dehydrogenase 2 (ALDH2) plays a crucial role in metabolizing toxic aldehydes, particularly in the heart. ALDH2 deficiency impacts cardiovascular health, especially in East Asians who frequently drink alcohol.

More Related Videos

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

Dissection Techniques and Histological Sampling of the Heart in Large Animal Models for Cardiovascular Diseases

Dissection Techniques and Histological Sampling of the Heart in Large Animal Models for Cardiovascular Diseases

Published on: June 16, 2022

Related Experiment Videos

Last Updated: Jan 21, 2026

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

Dissection Techniques and Histological Sampling of the Heart in Large Animal Models for Cardiovascular Diseases

Dissection Techniques and Histological Sampling of the Heart in Large Animal Models for Cardiovascular Diseases

Published on: June 16, 2022

Area of Science:

Biochemistry
Cardiovascular Biology
Mitochondrial Function

Background:

Aldehyde dehydrogenase 2 (ALDH2) is a key mitochondrial enzyme involved in aldehyde metabolism.
Emerging evidence highlights ALDH2's role in detoxifying reactive aldehydes generated during oxidative stress.
Cardiovascular diseases often involve mitochondrial dysfunction and oxidative stress.

Purpose of the Study:

To review the function of ALDH2 in cardiac pathological conditions.
To elucidate the link between ALDH2 deficiency, aldehyde toxicity, and cardiovascular disease.
To highlight the clinical implications of ALDH2 deficiency in East Asian populations with alcohol consumption.

Main Methods:

Literature review of ALDH2 function in cardiovascular pathology.
Analysis of studies on aldehyde toxicity and mitochondrial dysfunction.
Examination of epidemiological data on ALDH2 deficiency and cardiovascular disease.

Main Results:

ALDH2 is vital for metabolizing acetaldehyde and lipid peroxidation-derived aldehydes.
ALDH2 deficiency is associated with increased aldehyde toxicity and cardiovascular risks.
A significant portion of the East Asian population carries an ALDH2-deficient variant.

Conclusions:

ALDH2 plays a protective role in the cardiovascular system against aldehyde toxicity.
ALDH2 deficiency exacerbates cardiovascular disease risk, particularly when combined with alcohol consumption.
Understanding ALDH2's role is critical for managing cardiovascular health in susceptible populations.