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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

783
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

3.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.0K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

723
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
723
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

277
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
277
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

824
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
824
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

227
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
227

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Application of AlDeSense to Stratify Ovarian Cancer Cells Based on Aldehyde Dehydrogenase 1A1 Activity
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Aldehyde Dehydrogenase 2 and Heart Failure.

Wenjia Li1, Cheng Shen2, Lei Yin3

  • 1Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

Advances in Experimental Medicine and Biology
|August 2, 2019
PubMed
Summary
This summary is machine-generated.

Heart failure (HF) is a major global health issue, causing significant mortality and economic strain. This condition affects millions, with prevalence increasing in older adults, particularly those with diastolic dysfunction.

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Area of Science:

  • Cardiology
  • Public Health

Background:

  • Heart failure (HF) is a critical syndrome of cardiac dysfunction, marked by symptoms like breathlessness and edema.
  • It represents a final stage for many myocardial injuries, leading to widespread morbidity and mortality.
  • HF impacts over 23 million individuals globally, imposing substantial clinical and economic burdens.

Purpose of the Study:

  • To highlight the prevalence and impact of heart failure.
  • To underscore the economic implications of heart failure in healthcare systems.

Main Methods:

  • Literature review and data synthesis on heart failure prevalence and costs.
  • Analysis of demographic trends, including age-related increases in HF prevalence.

Main Results:

  • Heart failure affects millions worldwide, with significant morbidity and mortality.
  • Prevalence increases with age, reaching 36.0% in individuals over 60 with diastolic dysfunction.
  • HF accounts for 2-3% of healthcare expenditure in high-income nations, projected to double within 20 years.

Conclusions:

  • Heart failure represents a growing global health crisis with profound clinical and economic consequences.
  • The increasing prevalence in older populations necessitates urgent public health and healthcare system interventions.