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Multifunctionality of structural proteins in the enterovirus life cycle

Xingjian Wen1,2, Di Sun1, Jinlong Guo1

  • 1Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, PR China.

Future Microbiology
|August 2, 2019
PubMed

Insights

Enteroviruses impact human health, particularly in children. This review explores how viral structural proteins interact with host cells, offering potential targets for new antiviral therapies.

Area of Science:

  • Virology
  • Molecular Biology
  • Immunology

Background:

  • Enteroviruses significantly affect human health, especially in infants and children.
  • Viruses like Enteroviruses utilize host cellular processes for replication due to limited viral genome coding capacity.
  • Viral capsid-receptor interactions are critical for viral entry and pathogenesis.

Purpose of the Study:

  • To review the current understanding of the multifunctionality of Enterovirus structural proteins.
  • To highlight the role of these proteins in the viral life cycle.
  • To identify potential antiviral and therapeutic intervention targets.

Main Methods:

  • Literature review of existing research on Enterovirus structural proteins.
  • Analysis of viral protein interactions with cellular factors.
  • Examination of the role of capsid-receptor interactions in viral pathogenesis.

Main Results:

  • Enterovirus structural proteins are multifunctional, playing roles beyond virion assembly.
  • Interactions between structural proteins and host factors are essential for multiple stages of viral replication.
  • Capsid-receptor interactions are key determinants of viral entry and disease development.

Conclusions:

  • Enterovirus structural proteins are critical for viral replication and pathogenesis.
  • Understanding the multifaceted roles of these proteins can lead to novel antiviral strategies.
  • Targeting structural protein-host factor interactions presents a promising avenue for therapeutic interventions.
Keywords:
antiviral strategiesassemblyautophagycapsidcytolyticenterovirusneuropathogenesisreceptorstructural proteinviral tropism

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