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Substance Use Disorders Affecting Sleep01:24

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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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The Endocannabinoid System May Modulate Sleep Disorders in Aging.

Eric Murillo-Rodríguez1,2, Henning Budde2,3, André Barciela Veras2,4

  • 1Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, Division Ciencias de la Salud, Universidad Anahuac Mayab, Merida, Yucatan, Mexico.

Current Neuropharmacology
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The endocannabinoid system may impact sleep in aging, but current evidence is inconclusive. More research is needed to determine its therapeutic potential for age-related sleep disturbances.

Keywords:
AgingCannabidiolchildhoodpharmacologyrapid eye movement sleepsleep.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Pharmacology

Background:

  • Aging involves widespread biological changes affecting multiple systems.
  • Age-related diseases, including sleep disturbances, impact daily life and increase with global aging.
  • The endocannabinoid system shows promise for treating age-related conditions in preclinical models.

Purpose of the Study:

  • To explore the endocannabinoid system's role in regulating sleep-wake cycles in the aging population.
  • To review the current evidence on the endocannabinoid system's potential as a therapeutic target for sleep disorders in the elderly.

Main Methods:

  • Literature review focusing on the endocannabinoid system and aging-related sleep issues.
  • Analysis of experimental evidence regarding endocannabinoid system modulation of sleep-wake cycles.

Main Results:

  • The endocannabinoid system is implicated in modulating the sleep-wake cycle.
  • Evidence for the endocannabinoid system's efficacy in treating sleep disorders in aging is limited.

Conclusions:

  • The therapeutic efficacy of the endocannabinoid system for age-related sleep problems remains inconclusive.
  • Further research is required to fully understand and potentially utilize the endocannabinoid system for treating sleep disturbances in the elderly.