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Comparison of exhaled nitric oxide levels in pediatric patients with allergic rhinitis

Siwaporn Sapsaprang1, Pattara Tanticharoenwiwat2, Prapasri Kulalert2

  • 1Department of Pediatrics, Faculty of Medicine, Thammasat University Hospital, Pathum Thani, Thailand.

International Journal of Pediatric Otorhinolaryngology
|August 2, 2019
PubMed

Insights

Exhaled nitric oxide (eNO) levels are higher in children with allergic rhinitis (AR) compared to healthy children. Elevated eNO may help monitor AR severity and treatment effectiveness, even without asthma.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Biomarker Discovery

Background:

  • Allergic rhinitis (AR) is a common condition in children.
  • Accurate diagnosis and severity assessment are crucial for effective management.
  • Exhaled nitric oxide (eNO) is a potential non-invasive biomarker for airway inflammation.

Purpose of the Study:

  • To evaluate the diagnostic utility of eNO in distinguishing children with AR from healthy controls.
  • To investigate the correlation between eNO levels and AR disease severity in pediatric patients.

Main Methods:

  • A case-control study involving 80 children (5-15 years), with 40 diagnosed with AR and 40 healthy controls.
  • Measurement of exhaled nitric oxide (eNO) levels in all participants.
  • Comparison of eNO levels with ARIA-classified disease severity.

Main Results:

  • Children with AR exhibited significantly higher mean eNO levels (12.64 ± 14.67 ppb) compared to healthy controls (7.00 ± 6.33 ppb; p=0.046).
  • Persistent AR cases showed significantly higher eNO (17.11 ± 18.40 ppb) than intermittent AR (8.59 ± 8.88 ppb; p=0.024) and controls (p=0.008).
  • No significant association was found between eNO levels and gender, age, weight, or passive smoking in children with AR.

Conclusions:

  • Elevated eNO levels can help differentiate children with AR from healthy controls, even in the absence of asthma.
  • eNO shows potential as a valuable tool for monitoring allergic rhinitis severity and treatment response in children.
  • Clinicians should consider comorbid AR when using eNO for asthma monitoring.
Abstract

Keywords:
Exhaled nitric oxide (NO)Pediatric allergic rhinitis

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