Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Review and Preview01:10

Review and Preview

8.3K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.3K
Review and Preview01:13

Review and Preview

10.9K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
10.9K
Components of Stress01:23

Components of Stress

508
Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and...
508
Components of Language01:24

Components of Language

769
Language, whether spoken, signed, or written, consists of specific components: lexicon and grammar. The lexicon is the vocabulary of a language, comprising its words. Grammar is the set of rules used to convey meaning through the lexicon. For example, English grammar adds “-ed” to most verbs to indicate past tense. Words are formed by combining phonemes, which are the basic sound units of a language. Different languages have different sets of phonemes (e.g., “ah” vs.
769
Curvilinear Motion: Rectangular Components01:23

Curvilinear Motion: Rectangular Components

1.2K
Curvilinear motion characterizes the movement of a particle or object along a curved path, notably evident when envisioning a car navigating a winding road. If the car starts at point A, its position vector is established within a fixed frame of reference, where the ratio of the position vector to its magnitude signifies the unit vector pointing in the position vector's direction.
As the car advances, its position evolves over time. Quantifying the car's velocity involves computing the...
1.2K
Drug Binding to Blood Components01:30

Drug Binding to Blood Components

510
When drugs enter systemic circulation, they interact with various components of the blood, including proteins such as human serum albumin (HSA), α1-acid glycoprotein (AAG), lipoproteins, globulins, and red blood cells (RBCs).
HSA is the most abundant plasma protein and is vital in drug binding. It contains distinct drug-binding sites, with different drugs exhibiting affinity for specific sites. There are three main drug-binding domains for HSA: sites I, II, and III. These domains are...
510

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enantioseparation of Proton Pump Inhibitors by HPLC on Polysaccharide-Type Stationary Phases: Enantiomer Elution Order Reversal, Thermodynamic Characterization, and Hysteretic Effect.

International journal of molecular sciences·2025
Same author

Fast Determination of Furocoumarins in Food Supplements Containing <i>Heracleum sphondylium</i> L. Using Capillary Electrophoresis.

Foods (Basel, Switzerland)·2025
Same author

Pharmacognostic Evaluation and Antioxidant Profiling of Five Varieties of <i>Ribes nigrum</i> Grown in Romania.

Plants (Basel, Switzerland)·2025
Same author

Preparation and Characterization of Fenofibrate-Loaded Fibers Based on 2-Hydroxylpropyl-β-Cyclodextrin.

Polymers·2025
Same author

Marked differences in the effects of levetiracetam and its analogue brivaracetam on microglial, astrocytic, and neuronal density in the rat model of kainic acid-induced temporal lobe epilepsy.

Frontiers in pharmacology·2025
Same author

Dietary Habits and Their Correlation with Socio-Demographic Variables Among the Ethnic Hungarian Population of Romania.

Nutrients·2025

Related Experiment Video

Updated: Jan 21, 2026

Extraction of Venom and Venom Gland Microdissections from Spiders for Proteomic and Transcriptomic Analyses
10:25

Extraction of Venom and Venom Gland Microdissections from Spiders for Proteomic and Transcriptomic Analyses

Published on: November 3, 2014

34.5K

Hypotensive Snake Venom Components-A Mini-Review.

Orsolya Péterfi1, Francisc Boda2, Zoltán Szabó3

  • 1Faculty of Pharmacy, University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu Street No. 38, 540139 Tirgu Mures, Romania.

Molecules (Basel, Switzerland)
|August 3, 2019
PubMed
Summary

Snake venoms offer promising compounds for developing new antihypertensive drugs. These natural molecules, including bradykinin potentiating peptides and phospholipases A2, work through various cardiovascular mechanisms to lower blood pressure.

Keywords:
bradykinin potentiating peptideshypotensive peptidesnatriuretic peptidesphospholipases A2snake venom

More Related Videos

Harvesting Venom Toxins from Assassin Bugs and Other Heteropteran Insects
09:45

Harvesting Venom Toxins from Assassin Bugs and Other Heteropteran Insects

Published on: April 21, 2018

13.8K
Author Spotlight: Efficient Venom Extraction Method from Trichogramma Parasitoid Wasps
03:53

Author Spotlight: Efficient Venom Extraction Method from Trichogramma Parasitoid Wasps

Published on: October 6, 2023

2.1K

Related Experiment Videos

Last Updated: Jan 21, 2026

Extraction of Venom and Venom Gland Microdissections from Spiders for Proteomic and Transcriptomic Analyses
10:25

Extraction of Venom and Venom Gland Microdissections from Spiders for Proteomic and Transcriptomic Analyses

Published on: November 3, 2014

34.5K
Harvesting Venom Toxins from Assassin Bugs and Other Heteropteran Insects
09:45

Harvesting Venom Toxins from Assassin Bugs and Other Heteropteran Insects

Published on: April 21, 2018

13.8K
Author Spotlight: Efficient Venom Extraction Method from Trichogramma Parasitoid Wasps
03:53

Author Spotlight: Efficient Venom Extraction Method from Trichogramma Parasitoid Wasps

Published on: October 6, 2023

2.1K

Area of Science:

  • Pharmacology
  • Toxicology
  • Cardiovascular Medicine

Background:

  • Hypertension is a significant global health concern linked to cardiovascular and kidney diseases.
  • Snake venoms are a rich source of bioactive molecules impacting the cardiovascular system.
  • Existing research highlights various snake venom components with potential antihypertensive properties.

Purpose of the Study:

  • To review current knowledge on snake venom components with antihypertensive potential.
  • To elucidate the mechanisms of action for these hypotensive agents from snake venom.
  • To identify novel therapeutic leads for hypertension management.

Main Methods:

  • Literature review of scientific publications on snake venom and hypertension.
  • Analysis of identified snake venom components and their known biological activities.
  • Categorization of compounds based on their blood pressure-lowering mechanisms.

Main Results:

  • Snake venom contains diverse peptides and enzymes like bradykinin potentiating peptides, natriuretic peptides, and phospholipases A2 with hypotensive effects.
  • Bradykinin potentiating peptides inhibit angiotensin-converting enzyme and enhance bradykinin activity.
  • Phospholipases A2 reduce blood pressure via arachidonic acid production, leading to prostaglandin synthesis.

Conclusions:

  • Snake venom components represent a valuable resource for novel antihypertensive drug discovery.
  • Understanding their diverse mechanisms of action is crucial for pharmaceutical development.
  • Further research into these compounds could lead to effective treatments for hypertension.