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Chemerin and Cancer.
Oliver Treeck1, Christa Buechler2, Olaf Ortmann3
1Department of Obstetrics and Gynecology, University Medical Center Regensburg, 93053 Regensburg, Germany. otreeck@caritasstjosef.de.
International Journal of Molecular Sciences
|August 3, 2019
Summary
Chemerin, a protein involved in inflammation, has a complex role in cancer, potentially promoting or inhibiting tumor growth. Its receptors are found in most tissues, influencing cancer progression and patient survival.
Area of Science:
- Oncology
- Immunology
- Endocrinology
Background:
- Chemerin is a multifunctional adipokine with known roles in inflammation, adipogenesis, and glucose homeostasis.
- Emerging evidence highlights chemerin's significant involvement in various cancer types.
- Chemerin's receptors, including CMKLR1, GPR1, and CCRL2, are expressed in both normal and tumor tissues.
Purpose of the Study:
- To review the multifaceted role of chemerin and its receptors in cancer.
- To explore the controversial dual effects of chemerin (anti-tumoral vs. tumor-promoting).
- To investigate the association between chemerin/receptor expression in tumors and patient survival.
Main Methods:
- Comprehensive literature search of original research articles on chemerin in cancer via PubMed.
- Inclusion of meta-analyses of publicly available DNA microarray data.
- Analysis of expression data to correlate chemerin and receptor levels with patient survival outcomes.
Main Results:
- Chemerin exhibits controversial effects in cancer, acting as both an anti-tumoral and tumor-promoting factor.
- Mechanisms include modulating innate immune responses and influencing tumor angiogenesis.
- Expression levels of chemerin and its receptors in tumor tissues are linked to patient survival.
Conclusions:
- Chemerin and its receptors play a complex and significant role in cancer biology.
- Understanding these roles is crucial for developing targeted cancer therapies.
- Further research is warranted to elucidate the precise mechanisms and therapeutic potential.
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