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How Does SUMO Participate in Spindle Organization?

Ariane Abrieu1, Dimitris Liakopoulos2

  • 1CRBM, CNRS UMR5237, Université de Montpellier, 1919 route de Mende, 34090 Montpellier, France. ariane.abrieu@crbm.cnrs.fr.

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|August 3, 2019
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Summary

Small Ubiquitin-like Modifier (SUMO) protein regulates cellular processes, organizing protein assemblies and aiding disassembly. This review explores SUMOylation

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SUMOSUMO-targeted ubiquitin ligasesmicrotubule-associated proteinsmitosisspindle

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Small Ubiquitin-like Modifier (SUMO) proteins are crucial regulators in diverse cellular mechanisms.
  • SUMOylation is increasingly recognized for its roles in protein complex organization and disassembly.
  • While SUMO's functions in DNA repair and signaling are established, its role in mitosis remains less understood.

Purpose of the Study:

  • To review the role of SUMOylation in organizing spindle and kinetochore complexes during mitosis.
  • To summarize SUMO-conjugated proteins associated with microtubules and the spindle.
  • To discuss SUMOylation's contribution to protein assembly and SUMO-targeted ubiquitylation in kinetochore function.

Main Methods:

  • Literature review of existing studies on SUMOylation in mitosis.
  • Analysis of proteomic screens identifying SUMOylated microtubule- and spindle-associated proteins.
  • Synthesis of current knowledge on SUMO regulation of protein assemblies and kinetochore function.

Main Results:

  • SUMOylation modifies numerous kinetochore, microtubule, and spindle-associated proteins.
  • SUMOylation contributes to the organization of large protein assemblies on the spindle.
  • SUMO-targeted ubiquitylation plays a role in controlling kinetochore assembly and function.

Conclusions:

  • SUMOylation is a key regulator of spindle and kinetochore organization during mitosis.
  • Understanding SUMOylation's role offers insights into mitotic regulation and potential therapeutic targets.
  • SUMO and SUMO-mediated degradation may represent targets for antimitotic therapies.