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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Diffusion01:12

Diffusion

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Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Diffusion01:21

Diffusion

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Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
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Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

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Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
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Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

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Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
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Diffuse Involvement of Primary Colorectal Lymphoma Simulating Ulcerative Colitis.

Ji-Ye Kim1, Sun Hee Chang1, Han Seong Kim1

  • 1Department of Pathology, Inje University Ilsan Paik Hospital, Goyang, Korea.

Journal of Pathology and Translational Medicine
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Primary colorectal lymphoma can rarely present diffusely, mimicking colitis. Awareness of this rare presentation and atypical lymphocytes is crucial for accurate diagnosis, preventing misdiagnosis of inflammatory bowel disease.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Primary colorectal lymphoma is rare.
  • Diffuse involvement without a distinct mass can mimic inflammatory bowel disease, such as ulcerative colitis.
  • Early detection is challenging due to subtle endoscopic and histological findings.

Purpose of the Study:

  • To highlight a rare case of diffuse primary colorectal lymphoma presenting as ulcerative colitis.
  • To emphasize the diagnostic challenges in differentiating this lymphoma from colitis.
  • To underscore the importance of recognizing atypical lymphocytes in colonic biopsies.

Main Methods:

  • Case report of a 31-year-old woman with symptoms of colitis.
  • Review of endoscopic findings and multiple mucosal biopsies.
  • Histopathological analysis of colonic tissue.

Main Results:

  • The patient presented with diffuse colonic involvement mimicking ulcerative colitis.
  • Initial mucosal biopsies were inconclusive due to atypical lymphocytes admixed with lymphoplasmacytic infiltration.
  • The diagnosis of diffuse-type primary colorectal lymphoma was eventually established.

Conclusions:

  • Diffuse primary colorectal lymphoma is a rare entity that can masquerade as colitis.
  • Diagnostic vigilance is required, especially when faced with atypical lymphocytes in colonic biopsies.
  • Increased awareness among clinicians and pathologists is essential to avoid misdiagnosis.