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Published on: April 30, 2018
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A versatile induction heating system for magnetic hyperthermia studies under different experimental conditions.
Yaser Hadadian1, Mehran Azimbagirad1, Elcio A Navas1
1Department of Physics, FFCLRP, University of São Paulo, Ribeirao Preto, SP CEP 14040-901, Brazil.
The Review of Scientific Instruments
|August 3, 2019
Summary
This study presents a versatile magnetic hyperthermia system for cancer therapy. The novel device efficiently generates alternating magnetic fields using iron oxide nanoparticles, offering adjustable frequencies and field strengths for effective treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Magnetic hyperthermia is an emerging cancer therapy using magnetic nanoparticles to generate heat.
- Effective hyperthermia requires devices capable of producing variable radiofrequency magnetic fields.
- Current systems often lack versatility in field amplitude and frequency control.
Purpose of the Study:
- To design and evaluate a versatile magnetic hyperthermia system.
- To enable adjustable experimental setups for hyperthermia research.
- To assess the system's feasibility with iron oxide nanoparticles.
Main Methods:
- Developed a novel system based on the Mazzilli inverter, adaptable to LC tank circuits.
- Utilized iron oxide nanoparticles synthesized via coprecipitation.
- Tested the system with nanoparticles in solution and gelatin phantoms.
- Employed four distinct coil geometries (solenoids, pancake, Helmholtz-like).
Main Results:
- Achieved 18 different operation frequencies ranging from 63-530 kHz.
- Generated magnetic field strengths up to 27.2 kA/m.
- Successfully evaluated system performance under various experimental conditions and coil configurations.
Conclusions:
- The designed system offers a flexible platform for magnetic hyperthermia studies.
- The versatility in frequency and field strength is crucial for optimizing cancer therapy.
- The system demonstrates feasibility for preclinical and clinical hyperthermia research.
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