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Vitamin A deficiency in critically ill children with sepsis

Xuepeng Zhang1,2, Kaiying Yang2, Linwen Chen3

  • 1Pediatric Intensive Care Unit, Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, 610041, China.

Critical Care (London, England)
|August 3, 2019
PubMed

Insights

Critically ill children with sepsis frequently have vitamin A deficiency. This deficiency is linked to a higher risk of septic shock in pediatric patients.

Area of Science:

  • Pediatric critical care medicine
  • Nutritional immunology
  • Infectious disease epidemiology

Background:

  • Limited data exist on vitamin A status in critically ill children with sepsis.
  • The relationship between serum vitamin A levels and sepsis outcomes requires further investigation.

Purpose of the Study:

  • To determine the prevalence of vitamin A deficiency in critically ill children with sepsis.
  • To assess the association between vitamin A deficiency and clinical outcomes in pediatric sepsis.

Main Methods:

  • Prospective study involving critically ill septic children and healthy controls.
  • Serum vitamin A levels measured within 24 hours of admission.
  • Comparison of vitamin A status between groups and association with clinical outcomes, including septic shock.

Main Results:

  • High prevalence of vitamin A deficiency (58.8%) in septic children compared to controls (12.2%).
  • Vitamin A deficiency was independently associated with septic shock (OR 4.630).
  • Vitamin A levels showed an inverse association with Pediatric Risk of Mortality (PRISM) scores in septic children.

Conclusions:

  • Vitamin A deficiency is common in critically ill children with sepsis.
  • Vitamin A deficiency may serve as a potential marker for mortality in pediatric sepsis.
Abstract

Keywords:
PediatricsSepsisVitamin AVitamin A deficiency

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