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Updated: Jan 21, 2026

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea
Published on: January 24, 2018
Biologic stromal ring to manage stromal melting after intrastromal corneal ring segment implantation
Elias Jarade1, Mohamad Issa2, Wassef Chanbour2
1Beirut Eye and ENT Specialist Hospital, Beirut, Lebanon; Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon; Mediclinic Dubai Mall, Dubai, United Arab Emirates.
Abstract:
We report a new technique to replace a manufactured poly(methyl methacrylate) (PMMA) ring with a biologic stromal ring fashioned from human corneal donor tissue in eyes with stromal melting above the PMMA ring. The biologic stromal ring is prepared using manual or femtosecond laser trephination of a donor cornea to obtain a 360-degree ring that is denuded and adjusted to match the PMMA ring being replaced. The biologic ring is attached to the PMMA ring. The PMMA ring is pushed and retrieved from the other side, which installs the biologic ring in place. Six biologic stromal rings were implanted successfully in 5 eyes of 5 patients with previous stromal melting; no complications were reported up to 6 months postoperatively. The biologic stromal ring stopped and healed the melting, prevented further ring complications, and preserved the therapeutic refractive effect of the previously implanted PMMA ring.
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