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REM sleep behavior disorder predicts functional dependency in early Parkinson's disease
Ryul Kim1, Dallah Yoo1, Jin Hee Im1
1Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Parkinsonism & Related Disorders
|August 3, 2019
Summary
REM sleep behavior disorder (RBD) in early Parkinson's disease (PD) patients predicts functional dependency. Early identification of RBD may help anticipate disease progression and aid in managing Parkinson's disease outcomes.
Area of Science:
- Neurology
- Movement Disorders
- Sleep Medicine
Background:
- Parkinson's disease (PD) is a progressive neurodegenerative disorder.
- Non-motor symptoms are common in PD and can impact quality of life.
- Functional dependency is a significant outcome in PD progression.
Purpose of the Study:
- To investigate if non-motor symptoms predict the development of functional dependency in Parkinson's disease.
- To identify specific non-motor symptoms that serve as early indicators of functional decline in PD patients.
Main Methods:
- Utilized data from 405 newly diagnosed Parkinson's disease patients from the PPMI study.
- Assessed non-motor symptoms including neuropsychiatric, sleep, olfactory, and autonomic functions.
- Defined functional dependency using Schwab and England (S&E) scores and employed Cox regression for predictor analysis.
Main Results:
- Over 5 years, 17% of patients developed functional dependency.
- REM sleep behavior disorder (RBD), measured by the RBDSQ, was a significant predictor of dependency.
- RBD predicted dependency even at a stricter S&E score cut-off of 60%.
Conclusions:
- REM sleep behavior disorder (RBD) presence in early Parkinson's disease is linked to a higher risk of functional dependency.
- RBD may serve as an early prognostic marker for poorer outcomes in PD.
- These findings highlight the importance of assessing sleep disturbances in PD management.