Related Experiment Video
Updated: Jan 21, 2026

Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses
Published on: January 17, 2025
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis
Stephan C Collins1,2,3,4,5, Anna Mikhaleva6, Katarina Vrcelj7
1Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404, Illkirch, France.
Abstract:
Brain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here we analyze 118 neuroanatomical parameters in 1,566 mutant mouse lines and identify 198 genes whose disruptions yield NeuroAnatomical Phenotypes (NAPs), mostly affecting structures implicated in brain connectivity. Groups of functionally similar NAP genes participate in pathways involving the cytoskeleton, the cell cycle and the synapse, display distinct fetal and postnatal brain expression dynamics and importantly, their disruption can yield convergent phenotypic patterns. 17% of human unique orthologues of mouse NAP genes are known loci for cognitive dysfunction. The remaining 83% constitute a vast pool of genes newly implicated in brain architecture, providing the largest study of mouse NAP genes and pathways. This offers a complementary resource to human genetic studies and predict that many more genes could be involved in mammalian brain morphogenesis.
Related Concept Videos
Morphogenesis
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
pH Scale
Organization of Genes
Association Areas of the Cortex
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Associative Learning
Classical conditioning, also known...

