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Recognition of typhus group rickettsia-infected targets by human lymphokine-activated killer cells
1Infectious Diseases Department, Naval Medical Research Institute, Bethesda, Maryland 20814-5055.
Infection and Immunity
|September 1, 1988
Abstract:
Lymphokine-activated killer cells caused significant lysis of target cells infected with typhus group rickettsiae (TGR) but not cells infected with Rickettsia tsutsugamushi. Monoclonal and polyclonal antibodies against TGR or TGR-infected cells failed to bind specifically to infected targets, as determined by flow cytometry or by immunoprecipitation of radiolabeled cell surface proteins. Major unaltered antigenic determinants of TGR therefore cannot be detected on the surface of infected targets.