Effects of L-carnitine on physical performance in chronic respiratory insufficiency

¹Lung Physiopathology Laboratory, R.G.E. Unit, Ospedale Bussolengo, Verona, Italy.

International Journal of Clinical Pharmacology, Therapy, and Toxicology

|May 1, 1988

Abstract:

Bicycle ergometer exercise tests were used to study two groups of 10 subjects suffering from type A chronic respiratory insufficiency before and after a 4-week course of L-carnitine or placebo. Analysis of the ventilatory and metabolic response to physical exercise (60 watts) revealed an improved utilization of the bio-energetic substrates obtained with L-carnitine as compared to patients treated with placebo. The substantial change observed in ventilatory and metabolic response to exercise after L-carnitine is characterized by an appreciable production of lactate and by the stability of pCO2, pH and HCO3 values, which would appear to support the hypothesis of a reduced anaerobic metabolism requirement for energy purposes.

Related Concept Videos

Articles linked to this work by shared authors, journal, and citation graph.

Cost of influenza and influenza-like syndromes (I-LSs) in Italy: Results of a cross-sectional telephone survey on a representative sample of general population.

Respiratory medicine·2018

Prevalence of different comorbidities in COPD patients by gender and GOLD stage.

Multidisciplinary respiratory medicine·2015

Efficacy of erdosteine 900 versus 600 mg/day in reducing oxidative stress in patients with COPD exacerbations: Results of a double blind, placebo-controlled trial.

Pulmonary pharmacology & therapeutics·2015

Daily peer review of abnormal cervical smears in the assessment of individual practice as an additional method of internal quality control.

Cytopathology : official journal of the British Society for Clinical Cytology·2014

Changes of clinical outcomes and health care resources in moderate and in severe COPD treated uniquely with tiotropium 18 mcg od for twenty-four months.

Pulmonary pharmacology & therapeutics·2011

Efficacy and safety of azithromycin 1 g once daily for 3 days in the treatment of community-acquired pneumonia: an open-label randomised comparison with amoxicillin-clavulanate 875/125 mg twice daily for 7 days.

Journal of chemotherapy (Florence, Italy)·2008

See all related articles

Related Experiment Videos

Effects of L-carnitine on physical performance in chronic respiratory insufficiency

Related Concept Videos

Cost of influenza and influenza-like syndromes (I-LSs) in Italy: Results of a cross-sectional telephone survey on a representative sample of general population.

Prevalence of different comorbidities in COPD patients by gender and GOLD stage.

Efficacy of erdosteine 900 versus 600 mg/day in reducing oxidative stress in patients with COPD exacerbations: Results of a double blind, placebo-controlled trial.

Daily peer review of abnormal cervical smears in the assessment of individual practice as an additional method of internal quality control.

Changes of clinical outcomes and health care resources in moderate and in severe COPD treated uniquely with tiotropium 18 mcg od for twenty-four months.

Efficacy and safety of azithromycin 1 g once daily for 3 days in the treatment of community-acquired pneumonia: an open-label randomised comparison with amoxicillin-clavulanate 875/125 mg twice daily for 7 days.

Distribution of lidocaine and digoxin in heart tissues and aorta following intrapericardial administration.

Population pharmacokinetic analysis of new aminoglycosides, astromicin and isepamicin, and evaluation of Bayesian prediction method for approximation of individual clearance of drug.

Comparison of the pharmacokinetics of 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in healthy volunteers, with and without co-administration of ferrous sulfate, to thalassemia patients.

The effects of cimetidine, ranitidine and famotidine on the single-dose pharmacokinetics of naproxen and its metabolites in humans.

Is there a relationship between cytarabine pharmacokinetics and keratitis?--A case report.

Effect of DL-sodium lactate infusion on excretion of purine bases and oxypurinol.

Related Experiment Videos

Effects of L-carnitine on physical performance in chronic respiratory insufficiency

Abstract:

Related Concept Videos

Related Articles