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Updated: Jan 21, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Importance of Postprandial Glucose in Relation to A1C and Cardiovascular Disease
Kenneth S Hershon1, Barbara R Hirsch1, Ola Odugbesan2
1North Shore Diabetes and Endocrine Associates, New Hyde Park, NY.
Abstract:
IN BRIEF This article reviews the evidence regarding the impact of postprandial glucose (PPG) on overall A1C and its relation to cardiovascular disease (CVD). To date, four randomized, controlled trials have evaluated the impact of PPG reduction on CVD; however, only one of these successfully demonstrated a positive effect. Despite this, epidemiological evidence does indicate a cardiovascular benefit of PPG reduction, and agents that can be used to manage PPG in people with type 2 diabetes are also discussed.
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