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Antiangiogenic properties of nanoparticles: a systematic review

Brhaish Ali Saeed1, Vuanghao Lim1, Nor Adlin Yusof1

  • 1Integrative Medicine Cluster, Advanced Medical and Dental Institute, SAINS@ Bertam, Universiti Sains Malaysia, Kepala Batas 13200, Pulau Pinang, Malaysia.

International Journal of Nanomedicine
|August 3, 2019
PubMed

Insights

This review highlights nanoparticles for treating angiogenesis-related diseases. Spherical nanoparticles around 20 nm, especially gold nanoparticles, show promise for anti-angiogenesis therapy with adjustable toxicity.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Vascular Biology

Background:

  • Angiogenesis is crucial in various diseases.
  • Nanoparticles offer potential therapeutic benefits.
  • Understanding nanoparticle effects on angiogenesis is vital.

Purpose of the Study:

  • To systematically review the impact of nanoparticles on angiogenesis.
  • To identify key nanoparticle characteristics influencing therapeutic efficacy.

Main Methods:

  • Systematic literature review.
  • Inclusion/exclusion criteria for article selection.
  • Reference chaining for comprehensive search.

Main Results:

  • Spherical nanoparticles are commonly studied for angiogenesis.
  • Nanoparticle size is critical, with 20 nm being optimal.
  • Gold nanoparticles show significant anti-angiogenesis potential.
  • Toxicity is dose-dependent.

Conclusions:

  • Nanoparticles are promising for angiogenesis-related disease therapy.
  • Specific nanoparticle properties (shape, size) influence efficacy.
  • Gold nanoparticles represent a key therapeutic avenue.
Keywords:
angiogenesisantiangiogenesisnanoparticlesshapesizetoxicity

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