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Treatment of recurrent myopic macular hole using membrane of plasma rich in growth factors

Ronald M Sánchez-Ávila1, Álvaro Fernández-Vega González1, Álvaro Fernández-Vega Sanz1

  • 1University Institute Fernández-Vega, Ophthalmological Research Foundation, Oviedo, Spain.

International Medical Case Reports Journal
|August 3, 2019
PubMed
Abstract

Insights

This study shows that a plasma rich in growth factors (PRGF) membrane effectively treated a recurrent large myopic macular hole (MH). The PRGF membrane aided in the anatomic recovery and improved visual acuity in the patient.

Area of Science:

  • Ophthalmology
  • Regenerative Medicine

Background:

  • Recurrent large myopic macular holes (MH) pose a significant challenge in retinal surgery.
  • Standard surgical interventions may not always achieve complete closure or long-term success.

Purpose of the Study:

  • To report a case of successful treatment for a recurrent large myopic macular hole (MH).
  • To evaluate the efficacy of a plasma rich in growth factors (PRGF) membrane as an adjunctive therapy.

Main Methods:

  • A 71-year-old patient with a recurrent large myopic MH underwent pars plana vitrectomy with internal limiting membrane peeling.
  • An autologous PRGF-membrane was applied to the macular hole, followed by a fluid-gas exchange.
  • The patient was monitored for anatomical and visual outcomes.

Main Results:

  • The PRGF-membrane facilitated complete closure of the recurrent macular hole.
  • Anatomical recovery of the foveal depression was achieved.
  • Visual acuity improved to 0.1, with no adverse reactions or recurrences observed during six months of follow-up.

Conclusions:

  • Autologous PRGF-membrane serves as a viable adjunctive therapy for recurrent large myopic macular holes.
  • This approach can significantly improve both anatomical and visual outcomes in challenging MH cases.
Keywords:
PRGFmacular holemyopic macular holeplasma rich in growth factorsretinal surgery

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