Related Experiment Video
Updated: Jan 21, 2026
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
Effects of topical Vancomycin Dressing on Methicillin-Resistant Staphylococcus Aureus (MRSA) positive diabetic foot
Anas Bin Saif1, Sohail Jabbar2, Muhammad Saeed Akhtar3
1Dr. Anas Bin Saif, MBBS, FCPS Consultant General Surgeon, Department of Surgery, Combined Military Hospital, Kohat, Pakistan.
Objective:
To compare the effects of simple saline dressings versus topical vancomycin dressings on Methicillin-resistant Staphylococcus Aureus positive chronic diabetic foot ulcers.
Methods:
It was quasi experimental study conducted in Combined Military Hospital Kohat and PNS-Shifa Hospital Karachi from 01 January 2017 to 31 December 2017. A total of 23 patients were included based on non-probability convenient sampling who had diabetes and presented with foot ulcers for more than two weeks showing positive growth of Methicillin-Resistant Staphylococcus Aureus. The patients were treated with simple saline soaked dressings and debridement at first for three weeks followed by three weeks of topical vancomycin dressings with debridement. Thus patients served as their own controls.
Results:
The average change in surface area with saline dressing was +1.73 ±1.53cm2 per week whereas with vancomycin soaked dressing it was --0.06±1.60 cm2 per week (p <0.05). The average exudate also decreased from 1.78±1.23 to 0.99±0.72 (p<0.05) and same trend was observed in percentage of slough covering the ulcer from 45% ± 22.3% to 24.3% ±12.90% (p<0.05) with vancomycin dressing. Moreover, fifteen patients had negative culture for MRSA within 2 weeks.
Conclusion:
Vancomycin impregnated dressing in MRSA positive Diabetic foot may help achieve early healing as compared to simple conventional dressings with no systemic toxicity.
Insights
Topical vancomycin dressings significantly improved healing in Methicillin-resistant Staphylococcus Aureus (MRSA) positive diabetic foot ulcers compared to saline. This treatment reduced ulcer size, exudate, and slough, with no systemic toxicity observed.
Area of Science:
- Infectious Diseases
- Wound Healing
- Diabetology
Background:
- Diabetic foot ulcers are a significant complication of diabetes, often complicated by Methicillin-resistant Staphylococcus Aureus (MRSA) infections.
- Effective treatment strategies for MRSA-positive diabetic foot ulcers are crucial to prevent severe outcomes like amputation.
Purpose of the Study:
- To compare the efficacy of topical vancomycin dressings versus simple saline dressings in treating chronic diabetic foot ulcers positive for MRSA.
Main Methods:
- A quasi-experimental study involving 23 patients with MRSA-positive diabetic foot ulcers.
- Patients initially received saline dressings and debridement for three weeks, followed by three weeks of topical vancomycin dressings with debridement.
- Each patient served as their own control.
Main Results:
- Vancomycin dressings resulted in a significant decrease in ulcer surface area (-0.06 cm²/week) compared to saline dressings (+1.73 cm²/week).
- Average wound exudate decreased significantly, and the percentage of slough covering the ulcer was reduced with vancomycin treatment.
- Fifteen patients achieved negative MRSA cultures within two weeks of vancomycin application.
Conclusions:
- Topical vancomycin-impregnated dressings are effective in promoting early healing of MRSA-positive diabetic foot ulcers.
- This treatment approach offers a potential benefit over conventional saline dressings with no observed systemic toxicity.
More Related Videos
07:32Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus MRSA Infection
Published on: September 1, 2023
09:03Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus
Published on: September 5, 2013
Related Concept Videos
01:28Muscles of the Leg that Move the Foot and Toes
Anterior Compartment
The anterior compartment includes muscles that contribute to the dorsiflexion of the foot. This compartment houses the tibialis anterior, extensor hallucis longus, and extensor digitorum longus muscles....
01:28Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
02:32Position-effect Variegation
02:19Buffer Effectiveness
The buffer capacity is the amount of acid or base that can be added to a given volume...
01:30Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...