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Updated: Jan 21, 2026
09:41
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
9.1K
Multiple Myeloma with Intracytoplasmic Azurophilic Granules
Alireza Sadeghi1, Pardis Nematollahi2, Azadeh Moghaddas3
1Department of Medical Oncology and Hematology, Isfahan University of Medical Sciences, Isfahan, Iran.
Summary
Multiple myeloma diagnosis involves bone marrow examination. This study found rare intracytoplasmic granules in plasma cells, a finding linked to excess immunoglobulin deposition.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Bone marrow examination is crucial for diagnosing multiple myeloma.
- Certain multiple myeloma cases exhibit plasma cells with cytoplasmic inclusions.
- Intracytoplasmic inclusions in plasma cells are uncommon but diagnostically significant.
Observation:
- A 46-year-old man presented for multiple myeloma evaluation.
- Bone marrow aspiration revealed large, intracytoplasmic azurophilic granules.
- These granules mimicked intracellular microorganisms within plasma cells.
Findings:
- Immunohistochemistry (IHC) confirmed CD138 positivity in these cells.
- The observed granules represent a rare histologic finding in multiple myeloma.
- These inclusions are typically caused by excess immunoglobulin deposition.
Implications:
- This case highlights a rare morphologic variant in multiple myeloma diagnosis.
- Understanding these inclusions aids in accurate histopathological interpretation.
- Recognizing this finding can refine diagnostic criteria and treatment strategies for multiple myeloma.
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