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Updated: Jan 21, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Multiple Myeloma with Intracytoplasmic Azurophilic Granules
Alireza Sadeghi1, Pardis Nematollahi2, Azadeh Moghaddas3
1Department of Medical Oncology and Hematology, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract:
Bone marrow examination plays an important role in the diagnosis of multiple myeloma. In some cases with multiple myeloma, marrow plasma cells with cytoplasmic inclusions are seen. In this study, a 46-year- old man was evaluated for multiple myeloma. In bone marrow aspiration, large intracytoplasmic azurophilic granules, resembling intracellular microorganisms were seen. IHC study demonstrated that these cells are CD138 positive. This is a rare histologic finding that usually results from the deposition of excess immunoglobulin.
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