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Updated: Jan 21, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
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Multiple myeloma with testicular involvement: A case report.

Kaori Yamashita1, Toshihide Horiuchi1, Akihiro Hayashida1

  • 1Department of Urology, Tokyo Women's Medical University, Medical Center East, 2-1-10, Nishiogu, Arakawa-ku, Tokyo, 116-8567, Japan.

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Multiple myeloma rarely affects the testes as extramedullary disease. This case highlights a rare IgD lambda-type multiple myeloma with testicular infiltration, treated successfully with orchiectomy, chemotherapy, and radiation.

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Area of Science:

  • Hematology
  • Oncology
  • Urology

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • Extramedullary disease (EMD) occurs outside the bone marrow.
  • Testicular involvement in multiple myeloma is exceptionally rare.

Observation:

  • A 72-year-old male presented with IgD lambda-type multiple myeloma.
  • Testicular infiltration was identified as extramedullary disease.
  • The patient received a multimodal treatment approach.

Findings:

  • Successful management of testicular EMD in multiple myeloma was achieved.
  • The patient survived for at least eight months post-diagnosis.
  • Testicular involvement signifies a generally poor prognosis.

Implications:

  • This case contributes to understanding rare extramedullary manifestations of multiple myeloma.
  • Optimal treatment strategies for testicular multiple myeloma require further investigation.
  • Early recognition and management of testicular EMD may impact patient outcomes.