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Related Concept Videos

Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Anatomy of the Intestines01:23

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
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Physiological Barriers01:25

Physiological Barriers

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Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
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Small Intestine01:15

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The small intestine is primarily responsible for digestion and nutrient absorption. It spans from the pyloric sphincter to the ileocecal valve and connects to the large intestine.
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Large Intestine01:09

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The large intestine is divided into three main regions: the cecum, colon, and rectum. Extending from the ileocecal valve to the anus, it frames the small intestine on three sides.
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Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

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The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
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Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
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Intestinal barrier dysfunction in severe burn injury.

Wen He1, Yu Wang2, Pei Wang1

  • 1State Key Laboratory of Trauma, Burns, and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038 China.

Burns & Trauma
|August 3, 2019
PubMed
Summary

Severe burn injury disrupts the intestinal barrier, leading to serious complications. This review explores the mechanisms and new therapies for intestinal barrier dysfunction after burns.

Keywords:
BurnIntestinal barrier dysfunctionMyosin light chainMyosin light chain kinaseRho-associated protein kinaseTight junction

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Area of Science:

  • Burn injury research
  • Gastrointestinal physiology
  • Immunology

Background:

  • Severe burn injury frequently causes intestinal barrier dysfunction.
  • This dysfunction is linked to critical complications like shock, sepsis, and organ failure.
  • The intestinal epithelium's tight junctions are crucial for barrier integrity.

Purpose of the Study:

  • To review mechanisms of intestinal barrier dysfunction post-burn.
  • To discuss emerging therapeutic strategies for this condition.
  • To provide current knowledge on burn-induced gut barrier issues.

Main Methods:

  • Literature review of recent advances.
  • Analysis of signaling pathways involved in barrier disruption.
  • Synthesis of current understanding of mechanisms and therapies.

Main Results:

  • Burn injury triggers dysfunction via stress, hypoxia, and inflammation.
  • Multiple signaling pathways contribute to tight junction disruption.
  • Emerging therapies aim to restore intestinal barrier function.

Conclusions:

  • Intestinal barrier dysfunction is a key complication of severe burns.
  • Understanding underlying mechanisms is vital for developing effective treatments.
  • Further research into novel therapies is ongoing.