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Updated: Jan 21, 2026

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Synthesis of ynones at room temperature catalyzed by copper chloride cryptand complex under solvent free conditions
Sankar Jyoti Bora1, Bolin Chetia1
1Department of Chemistry, Dibrugarh University, Dibrugarh, 786004, Assam, India.
Abstract:
An air-stable highly efficient reusable CuCl2-cryptand-[2.2.Benzo] catalyst is reported first time for coupling reaction of terminal alkynes with different acyl chlorides in the presence of triethylamine acting both as base and solvent at room temperature to give the corresponding ynones. Easy-going, short reaction time, cost-effective, palladium-, phosphorus- and solvent-free, high yield and recyclability up to 5th times make this method green procedure for ynones' synthesis with wide substrate variety.
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