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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
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Annotation: travel and thrombosis.

Julia Czuprynska1, Roopen Arya1

  • 1King's College Hospital NHS Trust, London, UK.

British Journal of Haematology
|August 3, 2019
PubMed
Summary

Travel is a minor risk factor for venous thromboembolism (VTE), especially for those with existing risk factors. The duration of travel, not just air travel, is key. Life-threatening pulmonary embolism (PE) is rare.

Area of Science:

  • Medical research
  • Public health
  • Vascular medicine

Background:

  • Travel is recognized as a potential risk factor for venous thromboembolism (VTE).
  • The specific risks associated with travel, particularly long-duration travel, require further clarification.
  • Existing evidence on interventions for travel-related VTE is limited.

Purpose of the Study:

  • To evaluate travel as a risk factor for venous thromboembolism (VTE).
  • To assess the effectiveness of various preventive interventions for travel-related VTE.
  • To explore suitable anticoagulant options for thromboprophylaxis during travel.

Main Methods:

  • Review of existing literature on travel and VTE.
  • Analysis of risk factors associated with travel-related venous thromboembolism.
Keywords:
flightslong-haulthrombosistravelvenous thromboembolism

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  • Evaluation of evidence supporting interventions like graduated compression stockings (GCS) and anticoagulants.

    • Main Results:

    • Travel is a weak risk factor for VTE, primarily impacting passengers with additional risk factors.
    • The risk is associated with travel duration and not exclusive to air travel.
    • Evidence supporting interventions like GCS and low-molecular-weight heparin (LMWH) is limited.
    • Pulmonary embolism (PE) resulting from travel is rare.

    Conclusions:

    • Defining a population that benefits from thromboprophylaxis is challenging due to a lack of validated risk assessments.
    • While LMWH has been used, direct oral anticoagulants (DOACs) present a more convenient oral alternative for flight thromboprophylaxis.