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In hyperhidrosis quality of life is even worse than in acne, eczema, or psoriasis. A comparison of Skindex-16 and Dermatology Life Quality Index (DLQI).

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Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
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Postmenopausal craniofacial hyperhidrosis treated with botulinum toxin type B.

Philip Cabreus1, Carl Swartling1,2, Alma Rystedt1

  • 1Hidrosis Clinic, Stockholm, Sweden.

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|August 3, 2019
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Summary

Botulinum toxin (Btx) type B significantly improved quality of life for postmenopausal women with craniofacial hyperhidrosis. This safe and effective treatment offers hope for this often underrecognized condition.

Keywords:
NeuroBlocbotulinum toxinhyperhidrosispostmenopausesweating

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Area of Science:

  • Dermatology
  • Neurology
  • Women's Health

Background:

  • Hyperhidrosis significantly impacts patient quality of life.
  • Distinguishing postmenopausal hyperhidrosis from vasomotor symptoms is crucial for effective treatment.
  • Postmenopausal craniofacial hyperhidrosis is often underrecognized and challenging to manage.

Purpose of the Study:

  • To evaluate the efficacy and safety of botulinum toxin (Btx) type B in treating postmenopausal craniofacial hyperhidrosis.
  • To assess the impact of Btx type B on patients' quality of life using the Dermatology Life Quality Index (DLQI).

Main Methods:

  • A subgroup of eight postmenopausal patients with craniofacial hyperhidrosis participated in a randomized controlled trial.
  • Patients were randomized to receive either Btx type B or a placebo.
  • Quality of life was measured using the DLQI before and after treatment.

Main Results:

  • All patients receiving Btx type B showed improvement in DLQI scores, with a median decrease of 9 points (90% improvement).
  • The placebo group experienced a median increase of 2 points (-18% decline).
  • Open-label Btx type B treatment in the placebo group also resulted in significant DLQI score decrease (median 7 points, 91% improvement).

Conclusions:

  • Botulinum toxin (Btx) type B appears to be a safe and effective treatment for postmenopausal craniofacial hyperhidrosis.
  • The treatment led to significant improvements in quality of life for patients.
  • Further research is warranted to explore this treatment modality.