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Coeliac Disease and Mast Cells.

Barbara Frossi1, Marco De Carli2, Antonino Calabrò3,4

  • 1Department of Medical and Biological Science, University of Udine, 33100 Udine, Italy.

International Journal of Molecular Sciences
|August 3, 2019
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Summary

Mast cells play a crucial role in coeliac disease (celiac disease) pathogenesis. These innate immune cells increase in coeliac disease and promote a pro-inflammatory environment, contributing to disease progression.

Keywords:
25-mer fragment33-mer peptidecoeliac diseasegliadin immunologymast cellsp31-43 fragment

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Area of Science:

  • Immunology
  • Gastroenterology
  • Cell Biology

Background:

  • Coeliac disease results from complex environmental, genetic, and immunological interactions.
  • It is a T-cell-mediated disorder involving loss of tolerance to gluten and enterocyte damage.
  • Innate immune system activation precedes the gluten-specific T helper-1 response in coeliac disease.

Purpose of the Study:

  • To review studies investigating the role of mast cells in coeliac disease pathogenesis.
  • To understand mast cell involvement in the innate immune response during coeliac disease progression.

Main Methods:

  • Literature review of studies on mast cells and coeliac disease.
  • Analysis of data on mast cell numbers and function in coeliac disease.

Main Results:

  • Mast cells are key players in the innate immune response.
  • Mast cell numbers increase during coeliac disease progression.
  • Mast cells contribute to a pro-inflammatory microenvironment in coeliac disease.

Conclusions:

  • Mast cells are significantly involved in the pathogenesis of coeliac disease.
  • Targeting mast cells may offer therapeutic strategies for coeliac disease.