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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Novel Delivery Systems for Checkpoint Inhibitors

Purushottam Lamichhane1, Rahul Deshmukh2, Julie A Brown1

  • 1School of Dental Medicine, Lake Erie College of Osteopathic Medicine, 4800 Lakewood Ranch Blvd, Bradenton, FL 34211, USA.

Medicines (Basel, Switzerland)
|August 3, 2019
PubMed

Insights

Checkpoint inhibition (CPI) therapies offer powerful cancer treatment options. Targeted delivery methods aim to enhance efficacy and reduce side effects for broader patient application.

Area of Science:

  • Oncology
  • Immunotherapy
  • Drug Delivery Systems

Background:

  • Checkpoint inhibition (CPI) therapies are effective cancer treatments with significant clinical potential.
  • Immune-related adverse events are a major limitation, hindering the efficacy and widespread use of CPI.
  • Developing methods for sustained and tumor-targeted delivery of CPI is crucial for improving outcomes.

Purpose of the Study:

  • To review studies evaluating tumor-targeted delivery of checkpoint inhibitors.
  • To analyze the strengths and weaknesses of various delivery methods.
  • To discuss the future therapeutic potential of these delivery strategies.

Main Methods:

  • Literature review of studies on targeted delivery of checkpoint inhibitors.
  • Analysis of efficacy and safety data from evaluated methods.
  • Synthesis of findings to assess the outlook for therapeutic applications.

Main Results:

  • Various methods for tumor-targeted delivery of CPI have been investigated.
  • Targeted delivery shows promise in enhancing anti-cancer efficacy.
  • Reduced systemic toxicity is a key benefit of targeted delivery approaches.

Conclusions:

  • Tumor-targeted delivery of checkpoint inhibitors is a promising strategy.
  • These methods have the potential to improve therapeutic efficacy and minimize adverse events.
  • Further research and development are warranted for clinical translation.
Keywords:
DNA-encoded monoclonal antibodiesbacterial deliverydrug delivery systemshematopoietic stem cellshydrogelsimmune-related adverse eventsnanobodiesplatelets as delivery vehiclesresistance to checkpoint blockadeviral delivery of checkpoint inhibitors

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