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"Dark" Singlet Oxygen Made Easy.

Mohamed Elsherbini1, Rudolf K Allemann1, Thomas Wirth1

  • 1School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|August 3, 2019
PubMed
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A new continuous flow generator produces "dark" singlet oxygen for efficient chemical reactions. This method was successfully used to synthesize the antimalarial drug artemisinin.

Area of Science:

  • Organic Chemistry
  • Chemical Engineering
  • Medicinal Chemistry

Background:

  • Singlet oxygen is a highly reactive species used in various chemical transformations.
  • Generating singlet oxygen, especially in a controlled manner, presents challenges in synthetic chemistry.
  • Continuous flow chemistry offers advantages in safety, efficiency, and scalability for chemical reactions.

Purpose of the Study:

  • To develop an operationally simple continuous flow generator for "dark" singlet oxygen.
  • To demonstrate the efficiency of the generated singlet oxygen in reactions with chemical traps.
  • To apply the developed generator in the synthesis of a valuable pharmaceutical compound.

Main Methods:

  • Design and implementation of a continuous flow reactor system for "dark" singlet oxygen generation.
Keywords:
artemisininflow chemistryhydroperoxidesoxidationsinglet oxygen

Related Experiment Videos

  • Reaction of the generated singlet oxygen with various chemical substrates (traps).
  • Utilizing the flow generator for a key step in the synthesis of artemisinin.

    • Main Results:

    • Successful development of a continuous flow generator for "dark" singlet oxygen.
    • High yields of oxygenated products were obtained from reactions with chemical traps.
    • The generator proved effective in the synthesis of the antimalarial drug artemisinin.

    Conclusions:

    • The developed continuous flow generator provides a simple and efficient method for producing "dark" singlet oxygen.
    • This technology enables high-yield synthesis of oxygenated compounds.
    • The application in artemisinin synthesis highlights its potential in pharmaceutical manufacturing.