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Cranial and Spinal Meninges

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...

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Updated: Jan 21, 2026

Subtyping of Campylobacter jejuni ssp. doylei Isolates Using Mass Spectrometry-based PhyloProteomics MSPP

Subtyping of Campylobacter jejuni ssp. doylei Isolates Using Mass Spectrometry-based PhyloProteomics MSPP

Published on: October 30, 2016

[Campylobacter jejuni meningitis].

E Skripkina¹, A Canivet², M Wautier³

¹Service d'Anesthésie-Réanimation, CHU Liège, Belgique.

Revue Medicale De Liege

|August 3, 2019

Summary

This summary is machine-generated.

Campylobacter jejuni meningitis is rare, but this case highlights its potential in immunocompromised patients. Diagnosis was confirmed via stool culture and cerebrospinal fluid PCR, with successful treatment using meropenem.

Keywords:

Infection – Meningitis Campylobacter jejuni

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Culture Methods to Determine the Limit of Detection and Survival in Transport Media of Campylobacter Jejuni in Human Fecal Specimens

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Area of Science:

Infectious Diseases
Neurology
Microbiology

Background:

Campylobacter jejuni is a common cause of gastroenteritis but rarely causes meningitis.
Neurological complications of Campylobacter infections, including meningitis, are infrequently reported.
Factors like blood-brain barrier disruption and immunosuppression may predispose individuals to Campylobacter meningitis.

Observation:

A patient with a history of astrocytoma treated with chemotherapy and radiotherapy presented with gastroenteritis and meningitis.
Initial diagnosis was confirmed by stool cultures.
Cerebrospinal fluid (CSF) polymerase chain reaction (PCR) provided a definitive diagnosis of C. jejuni meningitis.

Findings:

Campylobacter jejuni bacteremia may be underdiagnosed due to the bacterium's thermophilic nature and specific culture requirements.
PCR is a sensitive and effective diagnostic tool for C. jejuni meningitis, particularly when blood cultures are negative or difficult to obtain.
The patient experienced a favorable outcome with meropenem treatment.

Implications:

This case highlights the importance of considering C. jejuni as a potential cause of meningitis in immunocompromised individuals.
Enhanced diagnostic strategies, including PCR, are crucial for timely identification and management of rare C. jejuni infections.
Further research is warranted to understand the pathogenesis and optimize treatment protocols for C. jejuni meningitis.