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Updated: Jan 21, 2026

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
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Published on: April 18, 2019

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Rapid review: next generation of cord blood banks; transplantation and beyond

Sergio Querol1, Dinara Samarkanova1

  • 1Cell Therapy Services, Banc de Sang i Teixits, Barcelona, Spain.

Transfusion
|August 3, 2019
PubMed

Cord blood (CB) is a medicinal product of human origin with unique cellular properties such as the presence of multipotent stem cells, naive immune cells, and fetal blood components. CB transplantation provides high rate of donor chimerism, and a good balance of graft-versus-host (GVH) and graft-versus-leukemia (GVL) effects. Use of CB for transplantation has decreased in recent years as haplo-identical stem cell transplants have achieved similar short-term clinical outcomes. For most patients, however, the optimal stem cell source remains unclear. CB inventories can be used as a starting material to develop new cellular medicines, and units with low cellular content can be converted to produce blood components like platelet-rich plasma and red blood cell (RBC) units for special indications.

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