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Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
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Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity01:15

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Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
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Bulk Modulus01:21

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The bulk modulus is a scientific term used to describe a material's resistance to uniform compression. It is the proportionality constant that links a change in pressure to the resulting relative volume change.
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Fineness Modulus01:19

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The fineness modulus (FM) of aggregate is a numerical index that measures the coarseness or fineness of the particles. It is calculated by adding the cumulative percentages of aggregate retained on each of a specified series of sieves and dividing the sum by 100.
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Bone Cells and Tissue01:30

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Related Experiment Video

Updated: Jan 21, 2026

Non-chromatographic Purification of Recombinant Elastin-like Polypeptides and their Fusions with Peptides and Proteins from Escherichia coli
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Drug-Loaded Elastin-Like Polypeptide-Collagen Hydrogels with High Modulus for Bone Tissue Engineering.

Pallabi Pal1, Quynh C Nguyen1, Angela H Benton2

  • 1Biomedical Materials Science, School of Dentistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.

Macromolecular Bioscience
|August 3, 2019
PubMed
Summary

This study developed collagen-ELP bone regenerative hydrogels with enhanced stiffness, promoting osteogenesis. The hydrogels effectively delivered bone morphogenetic protein-2 (rhBMP-2) and doxycycline, showing antimicrobial activity and supporting stem cell differentiation for bone repair.

Keywords:
anti-microbial propertydoxycyclinemechanical propertiesosteogenesisrhBMP-2

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Tri-layered Electrospinning to Mimic Native Arterial Architecture using Polycaprolactone, Elastin, and Collagen: A Preliminary Study
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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Hydrogel stiffness significantly influences cellular differentiation and tissue regeneration.
  • Developing effective bone regenerative materials requires strategies to enhance osteogenesis and prevent infection.

Purpose of the Study:

  • To create collagen and elastin-like polypeptide (ELP)-based hydrogels for bone regeneration.
  • To incorporate recombinant human bone morphogenetic protein-2 (rhBMP-2) and doxycycline to promote osteogenesis and combat infection.
  • To investigate the impact of hydrogel properties on stem cell behavior and differentiation.

Main Methods:

  • Fabrication of collagen-ELP hydrogels with tunable mechanical properties.
  • Incorporation and release kinetics study of rhBMP-2 and doxycycline.
  • Assessment of doxycycline's antimicrobial activity against relevant bacterial strains.
  • Evaluation of hydrogel architecture and its support for human adipose-derived stem cell attachment, proliferation, and morphology.
  • Analysis of osteogenic marker expression (alkaline phosphatase, osteocalcin).

Main Results:

  • Collagen-ELP hydrogels exhibited a higher modulus (35 ± 5 kPa) compared to collagen-only hydrogels.
  • Doxycycline showed biphasic release, while rhBMP-2 demonstrated a linear release profile.
  • Released doxycycline exhibited antimicrobial activity against Pseudomonas aeruginosa, Streptococcus sanguinis, and Escherichia coli.
  • Hydrogels possessed a macroporous 3D architecture supporting stem cell attachment, proliferation, and sheath formation.
  • Drug-loaded hydrogels maximized osteogenic marker expression, indicating enhanced osteogenesis.

Conclusions:

  • Drug-loaded collagen-ELP hydrogels possess suitable mechanical properties for osteogenesis.
  • These hydrogels effectively deliver rhBMP-2 and doxycycline, providing antimicrobial benefits and promoting stem cell differentiation.
  • The developed hydrogels show significant promise for combating bacterial infection and advancing guided bone regeneration.