Related Experiment Video
Updated: Jan 21, 2026
06:30
Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
Published on: August 27, 2021
3.6K
The development of inovirus-associated vector vaccines using phage-display technologies
Zachariah Stern1, Dora C Stylianou1, Leondios G Kostrikis1
1Department of Biological Sciences, University of Cyprus , Nicosia , Cyprus.
Expert Review of Vaccines
|August 3, 2019
Summary
Inovirus-associated vectors (IAVs) are versatile vaccine carriers derived from phages. They display antigens on their surface, effectively stimulating immune responses for disease prevention.
Area of Science:
- Microbiology
- Immunology
- Biotechnology
Background:
- Inovirus-associated vectors (IAVs) are derived from bacterial filamentous viruses (phages).
- IAVs function as vaccine carriers, eliciting cellular and humoral immune responses against various pathogens.
- Their unique ability to display specific antigen epitopes on coat proteins drives vaccine development.
Purpose of the Study:
- To review the development and applications of inovirus-based phage display vaccines.
- To explore the use of IAVs against a broad range of pathogens and hosts.
- To highlight the potential of IAVs in stimulating mucosal immunity.
Main Methods:
- Review of scientific literature on inovirus-based phage display vaccines.
- Selection of references from established databases based on expert knowledge.
- Analysis of architectural traits of filamentous viruses for antigen display.
Main Results:
- IAVs facilitate the display of specific antigenic peptides, inducing antibody production.
- Inoviruses offer a cost-efficient platform for large-scale phage display.
- Phage-display technology, including IAVs, is recognized for its importance (Nobel Prize 2018).
Conclusions:
- IAVs are a promising platform for developing novel vaccines against diverse diseases.
- The symbiotic nature of filamentous viruses provides an attractive route for stimulating mucosal immunity.
- Inovirus-based phage display offers a cost-effective and scalable approach to vaccine design.
Related Concept Videos
01:51Vaccinations
51.3K
Overview
51.3K
01:30Cancer Vaccines
984
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
984
01:31Hybridoma Technology
17.3K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
17.3K
01:22Scalar and Vectors
2.1K
In mechanics, commonly used terms like force, speed, velocity, and work can be classified as either scalar or vector quantities. A scalar is a physical quantity that can be described by its magnitude alone and does not require any directional components. Examples of scalar quantities are mass, area, and length.
Scalar quantities with the same physical units can be added or subtracted according to the usual algebra rules for numbers. For example, a class ending 10 min earlier than 50 min lasts...
Scalar quantities with the same physical units can be added or subtracted according to the usual algebra rules for numbers. For example, a class ending 10 min earlier than 50 min lasts...
2.1K
01:30Acceleration Vectors
21.7K
In everyday conversation, accelerating means speeding up. Acceleration is a vector in the same direction as the change in velocity, Δv, therefore the greater the acceleration, the greater the change in velocity over a given time. Since velocity is a vector, it can change in magnitude, direction, or both. Thus acceleration is a change in speed or direction, or both. For example, if a runner traveling at 10 km/h due east slows to a stop, reverses direction, and continues their run at 10 km/h...
21.7K
01:20Vector Operations
2.1K
Vectors are physical quantities that have both magnitude and direction. The vector operations include addition, subtraction, and scalar multiplication.
A vector multiplied by a scalar value is called scalar multiplication. The result obtained is a new vector with a different magnitude. If the scalar is positive, the direction of the vector remains the same, but if it is negative, the direction of the vector is reversed. For example, the product of the mass and velocity yields the momentum.
A vector multiplied by a scalar value is called scalar multiplication. The result obtained is a new vector with a different magnitude. If the scalar is positive, the direction of the vector remains the same, but if it is negative, the direction of the vector is reversed. For example, the product of the mass and velocity yields the momentum.
2.1K