Related Experiment Video

Updated: Jan 21, 2026

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

23.8K

Long-term antibiotics for Chronic Rhinosinusitis: changing views

W J Fokkens1

  • 1Department of Otorhinolaryngology, Amsterdam University Medical Centres, Location AMC Amsterdam, Amsterdam, The Netherlands.

Rhinology
|August 3, 2019
PubMed

Insights

Long-term macrolide antibiotics may help treat chronic rhinosinusitis (CRS) due to their anti-inflammatory and immune-modulating effects. This approach is based on positive outcomes observed in diffuse panbronchiolitis patients treated with antibiotics.

Area of Science:

  • Otolaryngology
  • Pulmonology
  • Pharmacology

Background:

  • Diffuse panbronchiolitis shows positive responses to long-term antibiotics.
  • Chronic rhinosinusitis (CRS) is a complex inflammatory condition.
  • Macrolides are a class of antibiotics with known anti-inflammatory properties.

Purpose of the Study:

  • To investigate the potential therapeutic effects of long-term macrolide use in chronic rhinosinusitis.
  • To evaluate the impact of macrolides on CRS symptomatology.

Main Methods:

  • Review of existing studies on macrolide treatment for CRS.
  • Analysis of data from Asian studies on antibiotic efficacy in related respiratory conditions.

Main Results:

  • Macrolides demonstrate anti-inflammatory and immune-modulating effects.
  • Evidence suggests potential benefits of long-term macrolides for CRS symptoms.

Conclusions:

  • Long-term macrolide therapy is a promising avenue for managing chronic rhinosinusitis.
  • Further research is warranted to confirm efficacy and optimal protocols for macrolide treatment in CRS.

More Related Videos

The Supraclavicular Fossa Ultrasound View for Central Venous Catheter Placement and Catheter Change Over Guidewire07:47

The Supraclavicular Fossa Ultrasound View for Central Venous Catheter Placement and Catheter Change Over Guidewire

Published on: December 23, 2014

20.0K
Antibiotic Dereplication Using the Antibiotic Resistance Platform10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.6K

Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

Overview
59.5K
Econometric Views (EViews)01:29

Econometric Views (EViews)

Econometric Views, often stylized as EViews, is a package that merges statistical analysis with econometric studies. It is designed to provide tools for time series analysis, forecasting, and econometric model simulation. The software originated from MicroTSP software and has evolved significantly since its inception in 1981. The history of EViews is marked by a continuous effort to enhance its computational speed and user interface. It was initially developed for large computing systems but...
566
Cranial Bones: Lateral View01:27

Cranial Bones: Lateral View

The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
4.4K
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.2K
Global Climate Change01:50

Global Climate Change

Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
28.7K
Work Done During Volume Change01:17

Work Done During Volume Change

In mechanics, work is done on an object when the force acting on it displaces the object. In thermodynamics, work done on a system can be estimated when the system's volume changes during any thermodynamic process.
Consider a gas confined to a cylinder fitted with a movable piston at one end. If the gas expands from volume V1 to volume V2, it exerts a force on the piston, such that the piston moves by a distance dr.
The work done by the gas on the piston can be expressed as
5.1K