Related Experiment Video
Updated: Jan 21, 2026

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye
Published on: August 16, 2014
Comparison of Corneal Biomechanics Between Low and High Myopic Eyes-A Meta-analysis
Wenjing Wu1, Rui Dou1, Yan Wang1
1Tianjin Eye Hospital & Eye Institute, Tianjin Ophthalmology Visual Science Key Laboratory, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Purpose:
To compare the corneal biomechanical difference between the low myopic eyes and high myopic eyes.
Design:
Systematic review and meta-analysis.
Methods:
Data sources, including PubMed, Medline, EMBASE, Web of Science, and Chinese databases including Wanfang and China National Knowledge Infrastructure, were searched to find the relevant studies. Primary outcomes were corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), Goldmann-correlated intraocular pressure (IOPg), and central corneal thickness (CCT) in high myopic eyes and low myopic eyes.
Results:
Eleven studies were enrolled in this study. CH and CRF were significantly higher in the low myopic eyes. The mean difference of CH was 0.73 mm Hg, 95% confidence interval (CI) [0.53 to 0.93], P < .001. The mean difference of CRF was 0.20 mm Hg, 95% CI [0.04 to 0.37], P = .02. The IOPcc and IOPg were significantly lower in the low myopic eyes. The mean difference of IOPcc was -2.53 mm Hg, 95% CI [-3.24, -1.83], P < .01. The mean difference of IOPg was -1.42 mm Hg, 95% CI [-2.26, -0.58], P = .0009. There was no significant difference between the 2 groups on CCT; the mean difference was -2.85 μm, 95% CI [-9.64.3.93], P = .41.
Conclusion:
Corneal biomechanics are different in the high myopic eyes. Low CH and CRF and high IOPcc and IOPg are suggested to be associated factors for high myopia. Future studies are needed to investigate the underlying corneal structure difference that causes the low CH and CRF value in the high myopic eyes.
Related Concept Videos
Directing Effect of Substituents: meta-Directing Groups
The Sense of Self: Reflected Self-Appraisal and Social Comparison
Multiple Comparison Tests
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
Evolutionary Relationships through Genome Comparisons
Comparison Between Electrical And Gravitational Forces
Since both are inverse square law forces, the distance gets canceled when the ratio of the two forces is considered. Instead, the ratio of the electrical and gravitational forces depends on...
Comparison between RL and RC circuits

